BDBM274764 N-(6-(4-(4-fluorophenyl)-1,2- dimethyl-1H-imidazol-5-yl) imidazo[1,2-b]pyridazin-2- yl)-4-phenyl-1,2,3- thiadiazole-5-carboxamide::US9556179, Compound 340

SMILES Cc1nc(c(-c2ccc3nc(NC(=O)c4snnc4-c4ccccc4)cn3n2)n1C)-c1ccc(F)cc1

InChI Key InChIKey=ILGHOMIIIJHANP-UHFFFAOYSA-N

Data  2 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 2 hits for monomerid = 274764   

TargetCasein kinase I isoform delta(Human)
Bristol-Myers Squibb

US Patent
LigandChemical structure of BindingDB Monomer ID 274764BDBM274764(N-(6-(4-(4-fluorophenyl)-1,2- dimethyl-1H-imidazol...)
Affinity DataIC50: 0.400nMpH: 7.4 T: 2°CAssay Description:The kinase assay was performed in V-bottom 384-well plates. The final assay volume was 30 μl prepared from 15 μl additions of enzyme, subst...More data for this Ligand-Target Pair
In Depth
Date in BDB:
12/12/2018
Entry Details
US Patent

TargetCasein kinase I isoform epsilon(Human)
Bristol-Myers Squibb

US Patent
LigandChemical structure of BindingDB Monomer ID 274764BDBM274764(N-(6-(4-(4-fluorophenyl)-1,2- dimethyl-1H-imidazol...)
Affinity DataIC50: 6.28nMpH: 7.4 T: 2°CAssay Description:The kinase assay was performed in V-bottom 384-well plates. The final assay volume was 30 μl prepared from 15 μl additions of enzyme, subst...More data for this Ligand-Target Pair
In Depth
Date in BDB:
12/12/2018
Entry Details
US Patent