BDBM278532 US10040790, Example 48::US10450313, Example 48::US10947230, Example 48::US11530214, Example 48::methyl [3-(2,6-difluoro-3,5-dimethoxyphenyl)-1,8-dimethyl-2-oxo-1,2,3,4-tetrahydropyrido [4,3-d]pyrimidin-7-yl]carbamate

SMILES COC(=O)Nc1ncc2CN(C(=O)N(C)c2c1C)c1c(F)c(OC)cc(OC)c1F

InChI Key InChIKey=NVLGODDPGOVSKJ-UHFFFAOYSA-N

Data  12 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
Find this compound or compounds like it in BindingDB:
   Substructure
Similarity at least:  must be >=0.5
Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 12 hits for monomerid = 278532   

TargetFibroblast growth factor receptor 1(Homo sapiens (Human))
Incyte Holdings

US Patent
LigandPNGBDBM278532(US10040790, Example 48 | US10450313, Example 48 | ...)
Affinity DataIC50: <100nMpH: 7.5Assay Description:The inhibitor potency of the exemplified compounds was measured in an enzyme assay that measures peptide phosphorylation using FRET measurements to d...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent
TargetFibroblast growth factor receptor 2(Homo sapiens (Human))
Incyte Holdings

US Patent
LigandPNGBDBM278532(US10040790, Example 48 | US10450313, Example 48 | ...)
Affinity DataIC50: <100nMMore data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent
TargetFibroblast growth factor receptor 3(Homo sapiens (Human))
Incyte Holdings

US Patent
LigandPNGBDBM278532(US10040790, Example 48 | US10450313, Example 48 | ...)
Affinity DataIC50: <100nMMore data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent
TargetFibroblast growth factor receptor 1(Homo sapiens (Human))
Incyte Holdings

US Patent
LigandPNGBDBM278532(US10040790, Example 48 | US10450313, Example 48 | ...)
Affinity DataIC50: <100nMAssay Description:The inhibitor potency of the exemplified compounds was measured in an enzyme assay that measures peptide phosphorylation using FRET measurements to d...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent
TargetFibroblast growth factor receptor 2(Homo sapiens (Human))
Incyte Holdings

US Patent
LigandPNGBDBM278532(US10040790, Example 48 | US10450313, Example 48 | ...)
Affinity DataIC50: <100nMAssay Description:The inhibitor potency of the exemplified compounds was measured in an enzyme assay that measures peptide phosphorylation using FRET measurements to d...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent
TargetFibroblast growth factor receptor 3(Homo sapiens (Human))
Incyte Holdings

US Patent
LigandPNGBDBM278532(US10040790, Example 48 | US10450313, Example 48 | ...)
Affinity DataIC50: <100nMAssay Description:The inhibitor potency of the exemplified compounds was measured in an enzyme assay that measures peptide phosphorylation using FRET measurements to d...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent
TargetFibroblast growth factor receptor 1(Homo sapiens (Human))
Incyte Holdings

US Patent
LigandPNGBDBM278532(US10040790, Example 48 | US10450313, Example 48 | ...)
Affinity DataIC50: <100nMAssay Description:The inhibitor potency of the exemplified compounds was measured in an enzyme assay that measures peptide phosphorylation using FRET measurements to d...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent
TargetFibroblast growth factor receptor 2(Homo sapiens (Human))
Incyte Holdings

US Patent
LigandPNGBDBM278532(US10040790, Example 48 | US10450313, Example 48 | ...)
Affinity DataIC50: <100nMAssay Description:The inhibitor potency of the exemplified compounds was measured in an enzyme assay that measures peptide phosphorylation using FRET measurements to d...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent
TargetFibroblast growth factor receptor 3(Homo sapiens (Human))
Incyte Holdings

US Patent
LigandPNGBDBM278532(US10040790, Example 48 | US10450313, Example 48 | ...)
Affinity DataIC50: <100nMAssay Description:The inhibitor potency of the exemplified compounds was measured in an enzyme assay that measures peptide phosphorylation using FRET measurements to d...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent
TargetFibroblast growth factor receptor 1(Homo sapiens (Human))
Incyte Holdings

US Patent
LigandPNGBDBM278532(US10040790, Example 48 | US10450313, Example 48 | ...)
Affinity DataIC50: <100nMAssay Description:The inhibitor potency of the exemplified compounds was measured in an enzyme assay that measures peptide phosphorylation using FRET measurements to d...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent
TargetFibroblast growth factor receptor 2(Homo sapiens (Human))
Incyte Holdings

US Patent
LigandPNGBDBM278532(US10040790, Example 48 | US10450313, Example 48 | ...)
Affinity DataIC50: <100nMAssay Description:The inhibitor potency of the exemplified compounds was measured in an enzyme assay that measures peptide phosphorylation using FRET measurements to d...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent
TargetFibroblast growth factor receptor 3(Homo sapiens (Human))
Incyte Holdings

US Patent
LigandPNGBDBM278532(US10040790, Example 48 | US10450313, Example 48 | ...)
Affinity DataIC50: <100nMAssay Description:The inhibitor potency of the exemplified compounds was measured in an enzyme assay that measures peptide phosphorylation using FRET measurements to d...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent