BDBM278755 N-(3-chloro-1-methyl- 1H-pyrazol-4-yl)-2- {[(1R,2S)-2- hydroxycyclohexyl] amino}pyrrolo[1,2- b]pyridazine-7- carboxamide trifluoroacetate::US10040798, Example 53

SMILES Cn1cc(NC(=O)c2ccc3ccc(N[C@@H]4CCCC[C@@H]4O)nn23)c(Cl)n1

InChI Key InChIKey=OUQILIAOKVOYQK-UHFFFAOYSA-N

Data  1 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 1 hit for monomerid = 278755   

TargetInterleukin-1 receptor-associated kinase 4(Human)
Merck Sharp & Dohme

US Patent
LigandChemical structure of BindingDB Monomer ID 278755BDBM278755(N-(3-chloro-1-methyl- 1H-pyrazol-4-yl)-2- {[(1R,2S...)
Affinity DataIC50: 55nMpH: 7.2Assay Description:The kinase activity of IRAK4 is determined by its ability to catalyze the phosphorylation of a fluorescent polypeptide substrate. The extent of phosp...More data for this Ligand-Target Pair
In Depth
Date in BDB:
12/22/2018
Entry Details
US Patent