BDBM278771 2-(1,4-diazepan-1-yl)- N-[4- (difluoromethyl)thiophen- 3-yl]pyrrolo[1,2- b]pyridazine-7- carboxamide trifluoroacetate::US10040798, Example 69

SMILES FC(F)c1cscc1NC(=O)c1ccc2ccc(nn12)N1CCCNCC1

InChI Key InChIKey=PCTWGJIOMGHDEX-UHFFFAOYSA-N

Data  1 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 1 hit for monomerid = 278771   

TargetInterleukin-1 receptor-associated kinase 4(Human)
Merck Sharp & Dohme

US Patent
LigandChemical structure of BindingDB Monomer ID 278771BDBM278771(2-(1,4-diazepan-1-yl)- N-[4- (difluoromethyl)thiop...)
Affinity DataIC50: 151nMpH: 7.2Assay Description:The kinase activity of IRAK4 is determined by its ability to catalyze the phosphorylation of a fluorescent polypeptide substrate. The extent of phosp...More data for this Ligand-Target Pair
In Depth
Date in BDB:
12/22/2018
Entry Details
US Patent