BDBM278826 2-{[(1R,2R)-2-amino- 3,3-difluorocyclohexyl] amino}-N-[1-methyl-3- (trifluoromethyl)-1H- pyrazol-4-yl] thieno[2,3-b] pyrazine-7- carboxamide trifluoroacetate::US10040802, Example 5

SMILES Cn1cc(NC(=O)c2csc3ncc(N[C@@H]4CCCC(F)(F)[C@@H]4N)nc23)c(n1)C(F)(F)F

InChI Key InChIKey=ZAUHUZZMXUMKJS-UHFFFAOYSA-N

Data  1 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 1 hit for monomerid = 278826   

TargetInterleukin-1 receptor-associated kinase 4(Human)
Merck Sharp & Dohme

US Patent
LigandChemical structure of BindingDB Monomer ID 278826BDBM278826(2-{[(1R,2R)-2-amino- 3,3-difluorocyclohexyl] amino...)
Affinity DataIC50: 332nMpH: 7.2Assay Description:The kinase activity of IRAK4 is determined by its ability to catalyze the phosphorylation of a fluorescent polypeptide substrate. The extent of phosp...More data for this Ligand-Target Pair
In Depth
Date in BDB:
12/22/2018
Entry Details
US Patent