BDBM278892 2-{[(1R,2R)-2-amino- 3,3-difluorocyclohexyl] amino}-N-(2- bromothiophen-3-yl) thieno[2,3-b] pyrazine-7- carboxamide trifluoroacetate::US10040802, Example 71

SMILES N[C@@H]1[C@@H](CCCC1(F)F)Nc1cnc2scc(C(=O)Nc3ccsc3Br)c2n1

InChI Key InChIKey=NDFPSUJMESNGHQ-UHFFFAOYSA-N

Data  1 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 1 hit for monomerid = 278892   

TargetInterleukin-1 receptor-associated kinase 4(Human)
Merck Sharp & Dohme

US Patent
LigandChemical structure of BindingDB Monomer ID 278892BDBM278892(2-{[(1R,2R)-2-amino- 3,3-difluorocyclohexyl] amino...)
Affinity DataIC50: 2.07E+3nMpH: 7.2Assay Description:The kinase activity of IRAK4 is determined by its ability to catalyze the phosphorylation of a fluorescent polypeptide substrate. The extent of phosp...More data for this Ligand-Target Pair
In Depth
Date in BDB:
12/22/2018
Entry Details
US Patent