BDBM280345 (S)-4-(2-(5-chloro-2-fluorophenyl)-5-isopropylpyridin-4-ylamino)-N-(2-hydroxypropyl)pyrimidine-5-carboxamide::US10030004, Compound 12a::US10501436, Compound 12a::US11053216, Compound 12a::US11702401, Compound 12a

SMILES C[C@H](O)CNC(=O)c1cncnc1Nc1cc(ncc1C(C)C)-c1cc(Cl)ccc1F

InChI Key InChIKey=HPZDDBNHJHAGNV-ZDUSSCGKSA-N

Data  20 IC50

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 20 hits for monomerid = 280345   

TargetSerine/threonine-protein kinase receptor R3(Homo sapiens (Human))
Medivation Technologies

US Patent

LigandBDBM280345((S)-4-(2-(5-chloro-2-fluorophenyl)-5-isopropylpyri...)Copy SMILESCopy InChI

Affinity DataIC50:  1.53E+3nMAssay Description:Compound of the invention were screened in an in vitro kinase assay against several members of the TGFβ family of Ser/Thr kinases. The kinases t...More data for this Ligand-Target Pair

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TargetTGF-beta receptor type-1(Homo sapiens (Human))
Medivation Technologies

US Patent

LigandBDBM280345((S)-4-(2-(5-chloro-2-fluorophenyl)-5-isopropylpyri...)Copy SMILESCopy InChI

Affinity DataIC50:  17.5nMAssay Description:Compound of the invention were screened in an in vitro kinase assay against several members of the TGFβ3 family of Ser/Thr kinases. The kinases ...More data for this Ligand-Target Pair

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TargetBone morphogenetic protein receptor type-1A(Homo sapiens (Human))
Medivation Technologies

US Patent

LigandBDBM280345((S)-4-(2-(5-chloro-2-fluorophenyl)-5-isopropylpyri...)Copy SMILESCopy InChI

Affinity DataIC50: >1.00E+5nMAssay Description:Compound of the invention were screened in an in vitro kinase assay against several members of the TGFβ family of Ser/Thr kinases. The kinases t...More data for this Ligand-Target Pair

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TargetActivin receptor type-1B(Homo sapiens (Human))
Medivation Technologies

US Patent

LigandBDBM280345((S)-4-(2-(5-chloro-2-fluorophenyl)-5-isopropylpyri...)Copy SMILESCopy InChI

Affinity DataIC50:  30.4nMAssay Description:Compound of the invention were screened in an in vitro kinase assay against several members of the TGFβ family of Ser/Thr kinases. The kinases t...More data for this Ligand-Target Pair

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TargetTGF-beta receptor type-1(Homo sapiens (Human))
Medivation Technologies

US Patent

LigandBDBM280345((S)-4-(2-(5-chloro-2-fluorophenyl)-5-isopropylpyri...)Copy SMILESCopy InChI

Affinity DataIC50:  17.5nMAssay Description:Compound of the invention were screened in an in vitro kinase assay against several members of the TGFβ family of Ser/Thr kinases. The kinases t...More data for this Ligand-Target Pair

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TargetSerine/threonine-protein kinase receptor R3(Homo sapiens (Human))
Medivation Technologies

US Patent

LigandBDBM280345((S)-4-(2-(5-chloro-2-fluorophenyl)-5-isopropylpyri...)Copy SMILESCopy InChI

Affinity DataIC50:  1.53E+3nMAssay Description:Compound of the invention were screened in an in vitro kinase assay against several members of the TGFβ family of Ser/Thr kinases. The kinases t...More data for this Ligand-Target Pair

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TargetActivin receptor type-1(Homo sapiens (Human))
Medivation Technologies

US Patent

LigandBDBM280345((S)-4-(2-(5-chloro-2-fluorophenyl)-5-isopropylpyri...)Copy SMILESCopy InChI

Affinity DataIC50:  9.97E+3nMAssay Description:Compound of the invention were screened in an in vitro kinase assay against several members of the TGFβ family of Ser/Thr kinases. The kinases t...More data for this Ligand-Target Pair

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Ligand InfoPC cidPC sid

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TargetBone morphogenetic protein receptor type-1A(Homo sapiens (Human))
Medivation Technologies

US Patent

LigandBDBM280345((S)-4-(2-(5-chloro-2-fluorophenyl)-5-isopropylpyri...)Copy SMILESCopy InChI

Affinity DataIC50: >1.00E+5nMAssay Description:Compound of the invention were screened in an in vitro kinase assay against several members of the TGFβ family of Ser/Thr kinases. The kinases t...More data for this Ligand-Target Pair

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TargetActivin receptor type-1B(Homo sapiens (Human))
Medivation Technologies

US Patent

LigandBDBM280345((S)-4-(2-(5-chloro-2-fluorophenyl)-5-isopropylpyri...)Copy SMILESCopy InChI

Affinity DataIC50:  30.4nMAssay Description:Compound of the invention were screened in an in vitro kinase assay against several members of the TGFβ family of Ser/Thr kinases. The kinases t...More data for this Ligand-Target Pair

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Ligand InfoPC cidPC sid

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TargetTGF-beta receptor type-1(Homo sapiens (Human))
Medivation Technologies

US Patent

LigandBDBM280345((S)-4-(2-(5-chloro-2-fluorophenyl)-5-isopropylpyri...)Copy SMILESCopy InChI

Affinity DataIC50:  17.5nMAssay Description:Compound of the invention were screened in an in vitro kinase assay against several members of the TGFβ family of Ser/Thr kinases. The kinases t...More data for this Ligand-Target Pair

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Ligand InfoPC cidPC sid

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TargetSerine/threonine-protein kinase receptor R3(Homo sapiens (Human))
Medivation Technologies

US Patent

LigandBDBM280345((S)-4-(2-(5-chloro-2-fluorophenyl)-5-isopropylpyri...)Copy SMILESCopy InChI

Affinity DataIC50:  1.53E+3nMAssay Description:Compound of the invention were screened in an in vitro kinase assay against several members of the TGFβ family of Ser/Thr kinases. The kinases t...More data for this Ligand-Target Pair

Target InfoPDBMMDBReactome pathwayKEGG
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Ligand InfoPC cidPC sid

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TargetActivin receptor type-1(Homo sapiens (Human))
Medivation Technologies

US Patent

LigandBDBM280345((S)-4-(2-(5-chloro-2-fluorophenyl)-5-isopropylpyri...)Copy SMILESCopy InChI

Affinity DataIC50:  9.97E+3nMMore data for this Ligand-Target Pair

Target InfoPDBKEGG
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Ligand InfoPC cidPC sid

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TargetBone morphogenetic protein receptor type-1A(Homo sapiens (Human))
Medivation Technologies

US Patent

LigandBDBM280345((S)-4-(2-(5-chloro-2-fluorophenyl)-5-isopropylpyri...)Copy SMILESCopy InChI

Affinity DataIC50: >1.00E+5nMMore data for this Ligand-Target Pair

Target InfoPDBReactome pathway
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TargetActivin receptor type-1B(Homo sapiens (Human))
Medivation Technologies

US Patent

LigandBDBM280345((S)-4-(2-(5-chloro-2-fluorophenyl)-5-isopropylpyri...)Copy SMILESCopy InChI

Affinity DataIC50:  30.4nMMore data for this Ligand-Target Pair

Target InfoPDBMMDBReactome pathwayKEGG
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Ligand InfoPC cidPC sid

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TargetTGF-beta receptor type-1(Homo sapiens (Human))
Medivation Technologies

US Patent

LigandBDBM280345((S)-4-(2-(5-chloro-2-fluorophenyl)-5-isopropylpyri...)Copy SMILESCopy InChI

Affinity DataIC50:  17.5nMMore data for this Ligand-Target Pair

Target InfoPDBMMDBReactome pathway
UniProtKB/SwissProt
B.MOADantibodypediaGoogleScholar

Ligand InfoPC cidPC sid

In DepthDetails US Patent
Copy BDB DOI

TargetSerine/threonine-protein kinase receptor R3(Homo sapiens (Human))
Medivation Technologies

US Patent

LigandBDBM280345((S)-4-(2-(5-chloro-2-fluorophenyl)-5-isopropylpyri...)Copy SMILESCopy InChI

Affinity DataIC50:  1.53E+3nMAssay Description:Compound of the invention were screened in an in vitro kinase assay against several members of the TGFβ3 family of Ser/Thr kinases. The kinases ...More data for this Ligand-Target Pair

Target InfoPDBMMDBReactome pathwayKEGG
UniProtKB/SwissProt
B.MOADDrugBankantibodypediaGoogleScholar

Ligand InfoPC cidPC sid

In DepthDetails US Patent
Copy BDB DOI

TargetActivin receptor type-1(Homo sapiens (Human))
Medivation Technologies

US Patent

LigandBDBM280345((S)-4-(2-(5-chloro-2-fluorophenyl)-5-isopropylpyri...)Copy SMILESCopy InChI

Affinity DataIC50:  9.97E+3nMAssay Description:Compound of the invention were screened in an in vitro kinase assay against several members of the TGFβ3 family of Ser/Thr kinases. The kinases ...More data for this Ligand-Target Pair

Target InfoPDBKEGG
UniProtKB/SwissProt
B.MOADDrugBankantibodypediaGoogleScholar

Ligand InfoPC cidPC sid

In DepthDetails US Patent
Copy BDB DOI

TargetBone morphogenetic protein receptor type-1A(Homo sapiens (Human))
Medivation Technologies

US Patent

LigandBDBM280345((S)-4-(2-(5-chloro-2-fluorophenyl)-5-isopropylpyri...)Copy SMILESCopy InChI

Affinity DataIC50: >1.00E+5nMAssay Description:Compound of the invention were screened in an in vitro kinase assay against several members of the TGFβ3 family of Ser/Thr kinases. The kinases ...More data for this Ligand-Target Pair

Target InfoPDBReactome pathway
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Ligand InfoPC cidPC sid

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TargetActivin receptor type-1B(Homo sapiens (Human))
Medivation Technologies

US Patent

LigandBDBM280345((S)-4-(2-(5-chloro-2-fluorophenyl)-5-isopropylpyri...)Copy SMILESCopy InChI

Affinity DataIC50:  30.4nMAssay Description:Compound of the invention were screened in an in vitro kinase assay against several members of the TGFβ3 family of Ser/Thr kinases. The kinases ...More data for this Ligand-Target Pair

Target InfoPDBMMDBReactome pathwayKEGG
UniProtKB/SwissProt
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Ligand InfoPC cidPC sid

In DepthDetails US Patent
Copy BDB DOI

TargetActivin receptor type-1(Homo sapiens (Human))
Medivation Technologies

US Patent

LigandBDBM280345((S)-4-(2-(5-chloro-2-fluorophenyl)-5-isopropylpyri...)Copy SMILESCopy InChI

Affinity DataIC50:  9.97E+3nMAssay Description:Compound of the invention were screened in an in vitro kinase assay against several members of the TGFβ family of Ser/Thr kinases. The kinases t...More data for this Ligand-Target Pair

Target InfoPDBKEGG
UniProtKB/SwissProt
B.MOADDrugBankantibodypediaGoogleScholar

Ligand InfoPC cidPC sid

In DepthDetails US Patent
Copy BDB DOI