BDBM281916 US10030016, Example 4.1.17::US10030016, Example 4.1.18::US10030016, Example 4.10::US10030016, Example 4.11::US10030016, Example 4.12::US10030016, Example 4.13::US10030016, Example 4.14::US10030016, Example 4.15::US10030016, Example 4.16::US10030016, Example 4.17::US10030016, Example 4.18::US10030016, Example 4.19::US10030016, Example 4.4::US10030016, Example 4.5::US10030016, Example 4.6::US10030016, Example 4.7::US10030016, Example 4.8::US10030016, Example 4.9

SMILES CCOC(=O)c1cccnc1NCc1cc(OC(C)C)cc(c1)-c1cn(c2ncc(cc12)C(=O)NC1CC1)S(=O)(=O)c1ccccc1

InChI Key InChIKey=NCISISXLYPFMTN-UHFFFAOYSA-N

Data  18 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
Find this compound or compounds like it in BindingDB:
   Substructure
Similarity at least:  must be >=0.5
Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 18 hits for monomerid = 281916   

Target3-phosphoinositide-dependent protein kinase 1 [51-359](Human)
Sunesis Pharmaceuticals

US Patent
LigandPNGBDBM281916(US10030016, Example 4.1.17 | US10030016, Example 4...)
Affinity DataIC50: >5.00E+3nMAssay Description:PDK1 (amino acids 51-359) and AKT2 (amino acids 140-467 fused to PIFtide, amino acids EEQEMFRDFDYIADW) were expressed as N-terminally tagged GST fusi...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent

Target3-phosphoinositide-dependent protein kinase 1 [51-359](Human)
Sunesis Pharmaceuticals

US Patent
LigandPNGBDBM281916(US10030016, Example 4.1.17 | US10030016, Example 4...)
Affinity DataIC50:  550nMAssay Description:PDK1 (amino acids 51-359) and AKT2 (amino acids 140-467 fused to PIFtide, amino acids EEQEMFRDFDYIADW) were expressed as N-terminally tagged GST fusi...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent

Target3-phosphoinositide-dependent protein kinase 1 [51-359](Human)
Sunesis Pharmaceuticals

US Patent
LigandPNGBDBM281916(US10030016, Example 4.1.17 | US10030016, Example 4...)
Affinity DataIC50: <100nMAssay Description:PDK1 (amino acids 51-359) and AKT2 (amino acids 140-467 fused to PIFtide, amino acids EEQEMFRDFDYIADW) were expressed as N-terminally tagged GST fusi...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent

Target3-phosphoinositide-dependent protein kinase 1 [51-359](Human)
Sunesis Pharmaceuticals

US Patent
LigandPNGBDBM281916(US10030016, Example 4.1.17 | US10030016, Example 4...)
Affinity DataIC50: <100nMAssay Description:PDK1 (amino acids 51-359) and AKT2 (amino acids 140-467 fused to PIFtide, amino acids EEQEMFRDFDYIADW) were expressed as N-terminally tagged GST fusi...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent

Target3-phosphoinositide-dependent protein kinase 1 [51-359](Human)
Sunesis Pharmaceuticals

US Patent
LigandPNGBDBM281916(US10030016, Example 4.1.17 | US10030016, Example 4...)
Affinity DataIC50: <100nMAssay Description:PDK1 (amino acids 51-359) and AKT2 (amino acids 140-467 fused to PIFtide, amino acids EEQEMFRDFDYIADW) were expressed as N-terminally tagged GST fusi...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent

Target3-phosphoinositide-dependent protein kinase 1 [51-359](Human)
Sunesis Pharmaceuticals

US Patent
LigandPNGBDBM281916(US10030016, Example 4.1.17 | US10030016, Example 4...)
Affinity DataIC50:  550nMAssay Description:PDK1 (amino acids 51-359) and AKT2 (amino acids 140-467 fused to PIFtide, amino acids EEQEMFRDFDYIADW) were expressed as N-terminally tagged GST fusi...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent

Target3-phosphoinositide-dependent protein kinase 1 [51-359](Human)
Sunesis Pharmaceuticals

US Patent
LigandPNGBDBM281916(US10030016, Example 4.1.17 | US10030016, Example 4...)
Affinity DataIC50: <100nMAssay Description:PDK1 (amino acids 51-359) and AKT2 (amino acids 140-467 fused to PIFtide, amino acids EEQEMFRDFDYIADW) were expressed as N-terminally tagged GST fusi...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent

Target3-phosphoinositide-dependent protein kinase 1 [51-359](Human)
Sunesis Pharmaceuticals

US Patent
LigandPNGBDBM281916(US10030016, Example 4.1.17 | US10030016, Example 4...)
Affinity DataIC50: <100nMAssay Description:PDK1 (amino acids 51-359) and AKT2 (amino acids 140-467 fused to PIFtide, amino acids EEQEMFRDFDYIADW) were expressed as N-terminally tagged GST fusi...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent

Target3-phosphoinositide-dependent protein kinase 1 [51-359](Human)
Sunesis Pharmaceuticals

US Patent
LigandPNGBDBM281916(US10030016, Example 4.1.17 | US10030016, Example 4...)
Affinity DataIC50: <100nMAssay Description:PDK1 (amino acids 51-359) and AKT2 (amino acids 140-467 fused to PIFtide, amino acids EEQEMFRDFDYIADW) were expressed as N-terminally tagged GST fusi...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent

Target3-phosphoinositide-dependent protein kinase 1 [51-359](Human)
Sunesis Pharmaceuticals

US Patent
LigandPNGBDBM281916(US10030016, Example 4.1.17 | US10030016, Example 4...)
Affinity DataIC50: <100nMAssay Description:PDK1 (amino acids 51-359) and AKT2 (amino acids 140-467 fused to PIFtide, amino acids EEQEMFRDFDYIADW) were expressed as N-terminally tagged GST fusi...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent

Target3-phosphoinositide-dependent protein kinase 1 [51-359](Human)
Sunesis Pharmaceuticals

US Patent
LigandPNGBDBM281916(US10030016, Example 4.1.17 | US10030016, Example 4...)
Affinity DataIC50: <100nMAssay Description:PDK1 (amino acids 51-359) and AKT2 (amino acids 140-467 fused to PIFtide, amino acids EEQEMFRDFDYIADW) were expressed as N-terminally tagged GST fusi...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent

Target3-phosphoinositide-dependent protein kinase 1 [51-359](Human)
Sunesis Pharmaceuticals

US Patent
LigandPNGBDBM281916(US10030016, Example 4.1.17 | US10030016, Example 4...)
Affinity DataIC50: <100nMAssay Description:PDK1 (amino acids 51-359) and AKT2 (amino acids 140-467 fused to PIFtide, amino acids EEQEMFRDFDYIADW) were expressed as N-terminally tagged GST fusi...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent

Target3-phosphoinositide-dependent protein kinase 1 [51-359](Human)
Sunesis Pharmaceuticals

US Patent
LigandPNGBDBM281916(US10030016, Example 4.1.17 | US10030016, Example 4...)
Affinity DataIC50: <100nMAssay Description:PDK1 (amino acids 51-359) and AKT2 (amino acids 140-467 fused to PIFtide, amino acids EEQEMFRDFDYIADW) were expressed as N-terminally tagged GST fusi...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent

Target3-phosphoinositide-dependent protein kinase 1 [51-359](Human)
Sunesis Pharmaceuticals

US Patent
LigandPNGBDBM281916(US10030016, Example 4.1.17 | US10030016, Example 4...)
Affinity DataIC50: <100nMAssay Description:PDK1 (amino acids 51-359) and AKT2 (amino acids 140-467 fused to PIFtide, amino acids EEQEMFRDFDYIADW) were expressed as N-terminally tagged GST fusi...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent

Target3-phosphoinositide-dependent protein kinase 1 [51-359](Human)
Sunesis Pharmaceuticals

US Patent
LigandPNGBDBM281916(US10030016, Example 4.1.17 | US10030016, Example 4...)
Affinity DataIC50: <100nMAssay Description:PDK1 (amino acids 51-359) and AKT2 (amino acids 140-467 fused to PIFtide, amino acids EEQEMFRDFDYIADW) were expressed as N-terminally tagged GST fusi...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent

Target3-phosphoinositide-dependent protein kinase 1 [51-359](Human)
Sunesis Pharmaceuticals

US Patent
LigandPNGBDBM281916(US10030016, Example 4.1.17 | US10030016, Example 4...)
Affinity DataIC50: <100nMAssay Description:PDK1 (amino acids 51-359) and AKT2 (amino acids 140-467 fused to PIFtide, amino acids EEQEMFRDFDYIADW) were expressed as N-terminally tagged GST fusi...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent

Target3-phosphoinositide-dependent protein kinase 1 [51-359](Human)
Sunesis Pharmaceuticals

US Patent
LigandPNGBDBM281916(US10030016, Example 4.1.17 | US10030016, Example 4...)
Affinity DataIC50:  3.00E+3nMAssay Description:PDK1 (amino acids 51-359) and AKT2 (amino acids 140-467 fused to PIFtide, amino acids EEQEMFRDFDYIADW) were expressed as N-terminally tagged GST fusi...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent

Target3-phosphoinositide-dependent protein kinase 1 [51-359](Human)
Sunesis Pharmaceuticals

US Patent
LigandPNGBDBM281916(US10030016, Example 4.1.17 | US10030016, Example 4...)
Affinity DataIC50: <100nMAssay Description:PDK1 (amino acids 51-359) and AKT2 (amino acids 140-467 fused to PIFtide, amino acids EEQEMFRDFDYIADW) were expressed as N-terminally tagged GST fusi...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent