BDBM282968 6-(1-cyclobutyl-4-(4-fluorophenyl)-1H-imidazol-5- yl)imidazo[1,2-a]pyridine-3-carboxamide::US10287295, Example 172'::US11352360, Example 172'::US9884868, Example 172'

SMILES NC(=O)c1cnc2ccc(cn12)-c1c(ncn1C1CCC1)-c1ccc(F)cc1

InChI Key InChIKey=FTCVMGYNDFLVEU-UHFFFAOYSA-N

Data  6 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
Find this compound or compounds like it in BindingDB:
   Substructure
Similarity at least:  must be >=0.5
Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 6 hits for monomerid = 282968   

TargetTGF-beta receptor type-1(Homo sapiens (Human))
Rigel Pharmaceuticals

US Patent
LigandPNGBDBM282968(6-(1-cyclobutyl-4-(4-fluorophenyl)-1H-imidazol-5- ...)
Affinity DataIC50:  0.5nMpH: 7.4 T: 2°CAssay Description:Assays for the compounds reported below were conducted in 1536-well plates and 2 mL reactions are prepared from addition of HIS-TGF-βR1 T204D or...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent
TargetTGF-beta receptor type-2(Homo sapiens (Human))
Rigel Pharmaceuticals

US Patent
LigandPNGBDBM282968(6-(1-cyclobutyl-4-(4-fluorophenyl)-1H-imidazol-5- ...)
Affinity DataIC50:  1.74E+3nMMore data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent
TargetTGF-beta receptor type-2(Homo sapiens (Human))
Rigel Pharmaceuticals

US Patent
LigandPNGBDBM282968(6-(1-cyclobutyl-4-(4-fluorophenyl)-1H-imidazol-5- ...)
Affinity DataIC50:  1.74E+3nMMore data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent
TargetTGF-beta receptor type-2(Homo sapiens (Human))
Rigel Pharmaceuticals

US Patent
LigandPNGBDBM282968(6-(1-cyclobutyl-4-(4-fluorophenyl)-1H-imidazol-5- ...)
Affinity DataIC50:  1.74E+3nMAssay Description:Assays for the compounds reported below were conducted in 1536-well plates and 2 mL reactions are prepared from addition of HIS-TGF-βR1 T204D or...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent
TargetTGF-beta receptor type-1(Homo sapiens (Human))
Rigel Pharmaceuticals

US Patent
LigandPNGBDBM282968(6-(1-cyclobutyl-4-(4-fluorophenyl)-1H-imidazol-5- ...)
Affinity DataIC50:  0.5nMAssay Description:Assays for the compounds reported below were conducted in 1536-well plates and 2 mL reactions are prepared from addition of HIS-TGF-βR1 T204D or...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent
TargetTGF-beta receptor type-1 [T204D](Homo sapiens (Human))
Rigel Pharmaceuticals

US Patent
LigandPNGBDBM282968(6-(1-cyclobutyl-4-(4-fluorophenyl)-1H-imidazol-5- ...)
Affinity DataIC50:  0.5nMAssay Description:Assays for the compounds reported below were conducted in 1536-well plates and 2 mL reactions are prepared from addition of HIS-TGF-βR1 T204D or...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent