BDBM285634 3-(4-chloro-3,5-difluoro-phenyl)-N-cyclopropyl-imidazo[1,2-b]pyridazine-2-carboxamide::US10077269, Example 104::US10669279, Example 104::US9598421, Example 104

SMILES Fc1cc(cc(F)c1Cl)-c1c(nc2cccnn12)C(=O)NC1CC1

InChI Key InChIKey=GYZISZRYVGZYRR-UHFFFAOYSA-N

Data  16 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
Find this compound or compounds like it in BindingDB:
   Substructure
Similarity at least:  must be >=0.5
Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 16 hits for monomerid = 285634   

TargetIsoform 4 of cAMP-specific 3',5'-cyclic phosphodiesterase 4A (RD1)(Homo sapiens (Human))
Pfizer

US Patent
LigandPNGBDBM285634(3-(4-chloro-3,5-difluoro-phenyl)-N-cyclopropyl-imi...)
Affinity DataIC50: <0.488nMAssay Description:The PDE4A3, PDE4B1, PDE4C1 and PDE4D3 assays use the Scintillation Proximity Assay (SPA) technology to measure the inhibition of human recombinant PD...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent
LigandPNGBDBM285634(3-(4-chloro-3,5-difluoro-phenyl)-N-cyclopropyl-imi...)
Affinity DataIC50:  145nMAssay Description:Inhibition of human recombinant PDE4D incubated for 30 mins by Scintillation Proximity AssayMore data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails PubMed
LigandPNGBDBM285634(3-(4-chloro-3,5-difluoro-phenyl)-N-cyclopropyl-imi...)
Affinity DataIC50:  4.69nMAssay Description:The PDE4A3, PDE4B1, PDE4C1 and PDE4D3 assays use the Scintillation Proximity Assay (SPA) technology to measure the inhibition of human recombinant PD...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent
LigandPNGBDBM285634(3-(4-chloro-3,5-difluoro-phenyl)-N-cyclopropyl-imi...)
Affinity DataIC50:  145nMAssay Description:The PDE4A3, PDE4B1, PDE4C1 and PDE4D3 assays use the Scintillation Proximity Assay (SPA) technology to measure the inhibition of human recombinant PD...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent
TargetcAMP-specific 3',5'-cyclic phosphodiesterase 4A(Homo sapiens (Human))
Pfizer

US Patent
LigandPNGBDBM285634(3-(4-chloro-3,5-difluoro-phenyl)-N-cyclopropyl-imi...)
Affinity DataIC50: <0.488nMAssay Description:The PDE4A3, PDE4B1, PDE4C1 and PDE4D3 assays use the Scintillation Proximity Assay (SPA) technology to measure the inhibition of human recombinant PD...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent
TargetcAMP-specific 3',5'-cyclic phosphodiesterase 4B(Homo sapiens (Human))
Pfizer

US Patent
LigandPNGBDBM285634(3-(4-chloro-3,5-difluoro-phenyl)-N-cyclopropyl-imi...)
Affinity DataIC50:  1.59nMMore data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent
TargetcAMP-specific 3',5'-cyclic phosphodiesterase 4C(Homo sapiens (Human))
Pfizer

US Patent
LigandPNGBDBM285634(3-(4-chloro-3,5-difluoro-phenyl)-N-cyclopropyl-imi...)
Affinity DataIC50:  4.69nMMore data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent
LigandPNGBDBM285634(3-(4-chloro-3,5-difluoro-phenyl)-N-cyclopropyl-imi...)
Affinity DataIC50:  145nMMore data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent
TargetcAMP-specific 3',5'-cyclic phosphodiesterase 4A(Homo sapiens (Human))
Pfizer

US Patent
LigandPNGBDBM285634(3-(4-chloro-3,5-difluoro-phenyl)-N-cyclopropyl-imi...)
Affinity DataIC50: <0.488nMAssay Description:Human PDE4A3 coding sequence (amino acids 2 to 825 from the sequence with accession number NP_001104779) was cloned into the baculovirus expression v...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent
TargetcAMP-specific 3',5'-cyclic phosphodiesterase 4B(Homo sapiens (Human))
Pfizer

US Patent
LigandPNGBDBM285634(3-(4-chloro-3,5-difluoro-phenyl)-N-cyclopropyl-imi...)
Affinity DataIC50:  1.59nMAssay Description:Human PDE4A3 coding sequence (amino acids 2 to 825 from the sequence with accession number NP_001104779) was cloned into the baculovirus expression v...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent
TargetcAMP-specific 3',5'-cyclic phosphodiesterase 4C(Homo sapiens (Human))
Pfizer

US Patent
LigandPNGBDBM285634(3-(4-chloro-3,5-difluoro-phenyl)-N-cyclopropyl-imi...)
Affinity DataIC50:  4.69nMAssay Description:Human PDE4A3 coding sequence (amino acids 2 to 825 from the sequence with accession number NP_001104779) was cloned into the baculovirus expression v...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent
LigandPNGBDBM285634(3-(4-chloro-3,5-difluoro-phenyl)-N-cyclopropyl-imi...)
Affinity DataIC50:  145nMAssay Description:Human PDE4A3 coding sequence (amino acids 2 to 825 from the sequence with accession number NP_001104779) was cloned into the baculovirus expression v...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent
TargetcAMP-specific 3',5'-cyclic phosphodiesterase 4A(Homo sapiens (Human))
Pfizer

US Patent
LigandPNGBDBM285634(3-(4-chloro-3,5-difluoro-phenyl)-N-cyclopropyl-imi...)
Affinity DataIC50: <0.488nMAssay Description:Inhibition of human recombinant PDE4A incubated for 30 mins by Scintillation Proximity AssayMore data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails PubMed
TargetcAMP-specific 3',5'-cyclic phosphodiesterase 4B(Homo sapiens (Human))
Pfizer

US Patent
LigandPNGBDBM285634(3-(4-chloro-3,5-difluoro-phenyl)-N-cyclopropyl-imi...)
Affinity DataIC50:  1.60nMAssay Description:Inhibition of human recombinant PDE4B incubated for 30 mins by Scintillation Proximity AssayMore data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails PubMed
TargetcAMP-specific 3',5'-cyclic phosphodiesterase 4C(Homo sapiens (Human))
Pfizer

US Patent
LigandPNGBDBM285634(3-(4-chloro-3,5-difluoro-phenyl)-N-cyclopropyl-imi...)
Affinity DataIC50:  4.70nMAssay Description:Inhibition of human recombinant PDE4C incubated for 30 mins by Scintillation Proximity AssayMore data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails PubMed
TargetcAMP-specific 3',5'-cyclic phosphodiesterase 4B [122-736,S654A](Homo sapiens (Human))
Pfizer

US Patent
LigandPNGBDBM285634(3-(4-chloro-3,5-difluoro-phenyl)-N-cyclopropyl-imi...)
Affinity DataIC50:  1.59nMAssay Description:The PDE4A3, PDE4B1, PDE4C1 and PDE4D3 assays use the Scintillation Proximity Assay (SPA) technology to measure the inhibition of human recombinant PD...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent