BDBM286096 3-(7-(methyl(7H-pyrrolo[2,3-d]pyrimidin-4-yl)amino)-5-azaspiro[2.4]heptan-5-yl)-3-oxopropanenitrile::US10081635, Example 55

SMILES CN(c1ncnc2[nH]ccc12)C1CN(C(=O)CC#N)CC12CC2

InChI Key InChIKey=VCBQNQKWRAHHIR-UHFFFAOYSA-N

Data  4 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 4 hits for monomerid = 286096   

TargetTyrosine-protein kinase JAK1(Human)
Yang Ji Chemical

US Patent
LigandChemical structure of BindingDB Monomer ID 286096BDBM286096(US10081635, Example 55 | 3-(7-(methyl(7H-pyrrolo[2...)
Affinity DataIC50: 29.3nMAssay Description:Kinases used were human-derived JAK1, JAK2, JAK3, and TYK2 (Millipore, Germany). Each of these kinases was diluted with a suitable buffer solution as...More data for this Ligand-Target Pair
In Depth
Date in BDB:
1/13/2019
Entry Details
US Patent

TargetNon-receptor tyrosine-protein kinase TYK2(Human)
Yang Ji Chemical

US Patent
LigandChemical structure of BindingDB Monomer ID 286096BDBM286096(US10081635, Example 55 | 3-(7-(methyl(7H-pyrrolo[2...)
Affinity DataIC50: 40.4nMAssay Description:Kinases used were human-derived JAK1, JAK2, JAK3, and TYK2 (Millipore, Germany). Each of these kinases was diluted with a suitable buffer solution as...More data for this Ligand-Target Pair
In Depth
Date in BDB:
1/13/2019
Entry Details
US Patent

TargetTyrosine-protein kinase JAK1(Human)
Yang Ji Chemical

US Patent
LigandChemical structure of BindingDB Monomer ID 286096BDBM286096(US10081635, Example 55 | 3-(7-(methyl(7H-pyrrolo[2...)
Affinity DataIC50: 148nMAssay Description:Kinases used were human-derived JAK1, JAK2, JAK3, and TYK2 (Millipore, Germany). Each of these kinases was diluted with a suitable buffer solution as...More data for this Ligand-Target Pair
In Depth
Date in BDB:
1/13/2019
Entry Details
US Patent

TargetTyrosine-protein kinase JAK3(Human)
Yang Ji Chemical

US Patent
LigandChemical structure of BindingDB Monomer ID 286096BDBM286096(US10081635, Example 55 | 3-(7-(methyl(7H-pyrrolo[2...)
Affinity DataIC50: 694nMAssay Description:Kinases used were human-derived JAK1, JAK2, JAK3, and TYK2 (Millipore, Germany). Each of these kinases was diluted with a suitable buffer solution as...More data for this Ligand-Target Pair
In Depth
Date in BDB:
1/13/2019
Entry Details
US Patent