BDBM286400 N-(1-(2-(6-(2-chloro-3,5-dimethoxyphenyl)-2-(methylamino)-7-oxopyrido[2,3-d]pyrimidin-8(7H)-yl)ethyl)piperidin-4-yl)acrylamide::US10294223, Cpd No. 3::US11078199, Cpd 3::US9567334, Example 3::US9815834, Compound 3

SMILES CNc1ncc2cc(-c3cc(OC)cc(OC)c3Cl)c(=O)n(CCN3CCC(CC3)NC(=O)C=C)c2n1

InChI Key InChIKey=AQIPZTFTBQQQFZ-UHFFFAOYSA-N

Data  4 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 4 hits for monomerid = 286400   

TargetFibroblast growth factor receptor 1(Human)
Principia Biopharma

US Patent
LigandChemical structure of BindingDB Monomer ID 286400BDBM286400(N-(1-(2-(6-(2-chloro-3,5-dimethoxyphenyl)-2-(methy...)
Affinity DataIC50: 16.5nMAssay Description:A Caliper-based kinase assay (Caliper Life Sciences, Hopkinton, Mass.) was used to measure inhibition of FGFR family (FGFR1, FGFR2, FGFR3, FGFR4) kin...More data for this Ligand-Target Pair
In Depth
Date in BDB:
1/16/2022
Entry Details
US Patent

TargetFibroblast growth factor receptor 1(Human)
Principia Biopharma

US Patent
LigandChemical structure of BindingDB Monomer ID 286400BDBM286400(N-(1-(2-(6-(2-chloro-3,5-dimethoxyphenyl)-2-(methy...)
Affinity DataIC50: 16.5nMT: 2°CAssay Description:A Caliper-based kinase assay (Caliper Life Sciences, Hopkinton, Mass.) was used to measure inhibition of FGFR family (FGFR1, FGFR2, FGFR3, FGFR4) kin...More data for this Ligand-Target Pair
In Depth
Date in BDB:
1/17/2019
Entry Details
US Patent

TargetFibroblast growth factor receptor 1(Human)
Principia Biopharma

US Patent
LigandChemical structure of BindingDB Monomer ID 286400BDBM286400(N-(1-(2-(6-(2-chloro-3,5-dimethoxyphenyl)-2-(methy...)
Affinity DataIC50: 16.5nMAssay Description:A Caliper-based kinase assay (Caliper Life Sciences, Hopkinton, Mass.) was used to measure inhibition of FGFR family (FGFR1, FGFR2, FGFR3, FGFR4) kin...More data for this Ligand-Target Pair
In Depth
Date in BDB:
3/10/2020
Entry Details
US Patent

TargetFibroblast growth factor receptor 1(Human)
Principia Biopharma

US Patent
LigandChemical structure of BindingDB Monomer ID 286400BDBM286400(N-(1-(2-(6-(2-chloro-3,5-dimethoxyphenyl)-2-(methy...)
Affinity DataIC50: 25nMAssay Description:A Caliper-based kinase assay (Caliper Life Sciences, Hopkinton, Mass.) was used to measure inhibition of FGFR family (FGFR1, FGFR2, FGFR3, FGFR4) kin...More data for this Ligand-Target Pair
In Depth
Date in BDB:
10/13/2019
Entry Details
US Patent