BDBM287527 (S) N-(1-(2-(6-(2,6-dichloro-3,5-dimethoxyphenyl)-2-(ethylamino)-7-oxopyrido[2,3-d]-pyrimidin-8(7H)-yl)ethyl)pyrrolidin-3-yl)acrylamide::US11078199, Cpd 139::US9567334, Example 139

SMILES CCNc1ncc2cc(-c3c(Cl)c(OC)cc(OC)c3Cl)c(=O)n(CCN3CC[C@@H](C3)NC(=O)C=C)c2n1

InChI Key InChIKey=RBWRYJYFTRHUFW-UHFFFAOYSA-N

Data  2 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 2 hits for monomerid = 287527   

TargetFibroblast growth factor receptor 1(Human)
Principia Biopharma

US Patent
LigandChemical structure of BindingDB Monomer ID 287527BDBM287527((S) N-(1-(2-(6-(2,6-dichloro-3,5-dimethoxyphenyl)-...)
Affinity DataIC50: 3.80nMT: 2°CAssay Description:A Caliper-based kinase assay (Caliper Life Sciences, Hopkinton, Mass.) was used to measure inhibition of FGFR family (FGFR1, FGFR2, FGFR3, FGFR4) kin...More data for this Ligand-Target Pair
In Depth
Date in BDB:
1/17/2019
Entry Details
US Patent

TargetFibroblast growth factor receptor 1(Human)
Principia Biopharma

US Patent
LigandChemical structure of BindingDB Monomer ID 287527BDBM287527((S) N-(1-(2-(6-(2,6-dichloro-3,5-dimethoxyphenyl)-...)
Affinity DataIC50: 3.80nMAssay Description:A Caliper-based kinase assay (Caliper Life Sciences, Hopkinton, Mass.) was used to measure inhibition of FGFR family (FGFR1, FGFR2, FGFR3, FGFR4) kin...More data for this Ligand-Target Pair
In Depth
Date in BDB:
1/16/2022
Entry Details
US Patent