BDBM288671 (E)-3-(3,5-difluoro-4-((1R,3R/1S,3S)-2-(2-fluoro-2-methylpropyl)-3-methyl-6-(1H-pyrazol-4-yl)-1,2,3,4-tetrahydrobenzofuro[2,3-c]pyridin-1-yl)phenyl)acrylic acid::US10087191, Example 88

SMILES CC1Cc2c(oc3ccc(cc23)-c2cn[nH]c2)C(N1CC(C)(C)F)c1c(F)cc(\C=C\C(O)=O)cc1F

InChI Key

Data  1 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
Find this compound or compounds like it in BindingDB:
   Substructure
Similarity at least:  must be >=0.5
Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 1 hit for monomerid = 288671   

TargetG-protein coupled estrogen receptor 1(Human)
Jiangsu Hengrui Medicine

US Patent
LigandPNGBDBM288671((E)-3-(3,5-difluoro-4-((1R,3R/1S,3S)-2-(2-fluoro-2...)
Affinity DataIC50:  1.22nMAssay Description:The compounds of the present invention have an inhibition effect on the binding of E (estrogen) to ER (estrogen receptor), thereby blocking the bindi...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent