BDBM289969 (1-Hydroxy-cyclopropyl)-(4-{6- [4-(2H-pyrazol-3-yl)-phenoxy]- imidazo[1,2-a]pyridin-2-ylmethyl}- piperazin-1-yl)-methanone::US9573957, Example 96

SMILES O=C(N1CCN(Cc2cn3cc(Oc4ccc(-c5ccn[nH]5)cc4)ccc3n2)CC1)C1(O)CC1

InChI Key InChIKey=NQONPQSBTZMHBZ-UHFFFAOYSA-N

Data  1 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 1 hit for monomerid = 289969   

TargetLeukotriene A-4 hydrolase(Human)
Boehringer Ingelheim International

US Patent
LigandChemical structure of BindingDB Monomer ID 289969BDBM289969((1-Hydroxy-cyclopropyl)-(4-{6- [4-(2H-pyrazol-3-yl...)
Affinity DataIC50: 1.20nMpH: 7.5 T: 2°CAssay Description:The compounds of the invention are assessed for the ability to interact with human LTA4 hydrolase in an enzymatic assay that measures the ability of ...More data for this Ligand-Target Pair
In Depth
Date in BDB:
1/23/2019
Entry Details
US Patent