BDBM29643 (6aS)-6-methyl-5,6,6a,7-tetrahydro-4H-dibenzo[de,g]quinoline-10,11-diol;hydrochloride::(S)-6-methyl-5,6,6a,7-tetrahydro-4H-dibenzo[de,g]quinoline-10,11-diol::Apomorphine,(+)::CHEMBL416288::MLS000028867::S(+)-10,11-DIHYDROXYAPORPHINE HYDROCHLORIDE::SMR000058671::US10864248, Compound 1::cid_6852389

SMILES CN1CCc2cccc-3c2[C@@H]1Cc1ccc(O)c(O)c-31

InChI Key InChIKey=VMWNQDUVQKEIOC-ZDUSSCGKSA-N

Data  6 KI  17 IC50  6 EC50

PDB links: 1 PDB ID matches this monomer.

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
Find this compound or compounds like it in BindingDB:
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Similarity at least:  must be >=0.5
Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 29 hits for monomerid = 29643   

TargetD(4) dopamine receptor(Homo sapiens (Human))
University Of Toronto

Curated by PDSP Ki Database
LigandPNGBDBM29643((6aS)-6-methyl-5,6,6a,7-tetrahydro-4H-dibenzo[de,g...)
Affinity DataKi:  42nMMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetD(1A)/D(2) dopamine receptor(BOVINE)
Northeastern University

Curated by ChEMBL
LigandPNGBDBM29643((6aS)-6-methyl-5,6,6a,7-tetrahydro-4H-dibenzo[de,g...)
Affinity DataKi:  47nMAssay Description:Agonistic activity against calf striatal Dopamine receptor using [3H]- ADTN radioligandMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetD(2) dopamine receptor(Rattus norvegicus (rat))
Northeastern University

Curated by ChEMBL
LigandPNGBDBM29643((6aS)-6-methyl-5,6,6a,7-tetrahydro-4H-dibenzo[de,g...)
Affinity DataKi:  58nMAssay Description:Binding affinity at rat striatal Dopamine receptor D2 using [3H]- piperone radioligandMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetD(2) dopamine receptor(Homo sapiens (Human))
University Of Toronto

Curated by PDSP Ki Database
LigandPNGBDBM29643((6aS)-6-methyl-5,6,6a,7-tetrahydro-4H-dibenzo[de,g...)
Affinity DataKi:  286nMMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetDisabled homolog 2(Human)
Trustees Of Dartmouth College

US Patent
LigandPNGBDBM29643((6aS)-6-methyl-5,6,6a,7-tetrahydro-4H-dibenzo[de,g...)
Affinity DataKi:  1.92E+3nMAssay Description:Fluorescence polarization (FP) data were measured on a microplate reader (Tecan Infinite M1000, Mannedorf, Switzerland) at 27° C. For Kd measurements...More data for this Ligand-Target Pair
In DepthDetails US Patent
TargetD(1A) dopamine receptor(RAT)
Northeastern University

Curated by ChEMBL
LigandPNGBDBM29643((6aS)-6-methyl-5,6,6a,7-tetrahydro-4H-dibenzo[de,g...)
Affinity DataKi:  2.98E+3nMAssay Description:Binding affinity at rat striatal Dopamine receptor D1 using [3H]- SCH-23390 radioligandMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetGlutathione S-transferase Mu 1(Homo sapiens (Human))
Nmmlsc

Curated by PubChem BioAssay
LigandPNGBDBM29643((6aS)-6-methyl-5,6,6a,7-tetrahydro-4H-dibenzo[de,g...)
Affinity DataEC50:  3.08E+4nMAssay Description:University of New Mexico Assay Overview: Assay Support: NIH 1X01 MH079850-01 HTS to identify small molecule regulators of Bcl-2 family protein int...More data for this Ligand-Target Pair
In DepthDetails PCBioAssay
TargetBcl-2-like protein 2(Homo sapiens (Human))
Nmmlsc

Curated by PubChem BioAssay
LigandPNGBDBM29643((6aS)-6-methyl-5,6,6a,7-tetrahydro-4H-dibenzo[de,g...)
Affinity DataEC50:  9.95E+3nMAssay Description:University of New Mexico Assay Overview: Assay Support: NIH 1X01 MH079850-01 HTS to identify small molecule regulators of Bcl-2 family protein int...More data for this Ligand-Target Pair
In DepthDetails PCBioAssay
TargetApoptosis regulator Bcl-2(Homo sapiens (Human))
Nmmlsc

Curated by PubChem BioAssay
LigandPNGBDBM29643((6aS)-6-methyl-5,6,6a,7-tetrahydro-4H-dibenzo[de,g...)
Affinity DataEC50:  1.61E+4nMAssay Description:University of New Mexico Assay Overview: Assay Support: NIH 1X01 MH079850-01 HTS to identify small molecule regulators of Bcl-2 family protein int...More data for this Ligand-Target Pair
In DepthDetails PCBioAssay
LigandPNGBDBM29643((6aS)-6-methyl-5,6,6a,7-tetrahydro-4H-dibenzo[de,g...)
Affinity DataEC50:  3.86E+4nMAssay Description:University of New Mexico Assay Overview: Assay Support: NIH 1X01 MH079850-01 HTS to identify small molecule regulators of Bcl-2 family protein int...More data for this Ligand-Target Pair
In DepthDetails PCBioAssay
TargetEukaryotic translation initiation factor 4 gamma 1(Homo sapiens (Human))
Emory University

Curated by PubChem BioAssay
LigandPNGBDBM29643((6aS)-6-methyl-5,6,6a,7-tetrahydro-4H-dibenzo[de,g...)
Affinity DataIC50:  6.40E+4nMAssay Description:Dose Response Confirmation for Small Molecule Inhibitors of Eukaryotic Translation Initiation NIH Molecular Libraries Screening Centers Network [MLSC...More data for this Ligand-Target Pair
In DepthDetails PCBioAssay
LigandPNGBDBM29643((6aS)-6-methyl-5,6,6a,7-tetrahydro-4H-dibenzo[de,g...)
Affinity DataIC50:  400nMAssay Description:NIH Molecular Libraries Screening Centers Network [MLSCN] Emory Chemical Biology Discovery Center in MLSCN Assay provider: Nikolovska-Coleska, Univer...More data for this Ligand-Target Pair
In DepthDetails PCBioAssay
TargetM18 aspartyl aminopeptidase(Plasmodium falciparum 3D7)
The Scripps Research Institute Molecular Screening Center

Curated by PubChem BioAssay
LigandPNGBDBM29643((6aS)-6-methyl-5,6,6a,7-tetrahydro-4H-dibenzo[de,g...)
Affinity DataIC50:  3.10E+3nMAssay Description:Source (MLPCN Center Name): The Scripps Research Institute Molecular Screening Center Affiliation: The Scripps Research Institute, TSRI Assay Provide...More data for this Ligand-Target Pair
In DepthDetails PCBioAssay
TargetProcathepsin L(Homo sapiens (Human))
The Scripps Research Institute Molecular Screening Center

Curated by PubChem BioAssay
LigandPNGBDBM29643((6aS)-6-methyl-5,6,6a,7-tetrahydro-4H-dibenzo[de,g...)
Affinity DataIC50: >5.96E+4nMAssay Description:Source (MLPCN Center Name): The Scripps Research Institute Molecular Screening Center Affiliation: The Scripps Research Institute, TSRI Assay Provide...More data for this Ligand-Target Pair
In DepthDetails PCBioAssay
TargetGlucose-6-phosphate 1-dehydrogenase(Homo sapiens (Human))
Burnham Center For Chemical Genomics

Curated by PubChem BioAssay
LigandPNGBDBM29643((6aS)-6-methyl-5,6,6a,7-tetrahydro-4H-dibenzo[de,g...)
Affinity DataIC50:  3.84E+4nMAssay Description:Data Source: Sanford-Burnham Center for Chemical Genomics (SBCCG) Source Affiliation: Sanford-Burnham Medical Research Institute (SBMRI, San Diego CA...More data for this Ligand-Target Pair
In DepthDetails PCBioAssay
TargetGlucose-6-phosphate dehydrogenase-6-phosphogluconolactonase(Plasmodium falciparum 3D7)
Burnham Center For Chemical Genomics

Curated by PubChem BioAssay
LigandPNGBDBM29643((6aS)-6-methyl-5,6,6a,7-tetrahydro-4H-dibenzo[de,g...)
Affinity DataIC50:  8.36E+3nMAssay Description:Data Source: Sanford-Burnham Center for Chemical Genomics (SBCCG) Source Affiliation: Sanford-Burnham Medical Research Institute (SBMRI, San Diego CA...More data for this Ligand-Target Pair
In DepthDetails PCBioAssay
TargetGlucose-6-phosphate dehydrogenase-6-phosphogluconolactonase(Plasmodium falciparum 3D7)
Burnham Center For Chemical Genomics

Curated by PubChem BioAssay
LigandPNGBDBM29643((6aS)-6-methyl-5,6,6a,7-tetrahydro-4H-dibenzo[de,g...)
Affinity DataIC50: >8.00E+4nMAssay Description:Data Source: Sanford-Burnham Center for Chemical Genomics (SBCCG) Source Affiliation: Sanford-Burnham Medical Research Institute (SBMRI, San Diego CA...More data for this Ligand-Target Pair
In DepthDetails PCBioAssay
TargetGlucose-6-phosphate dehydrogenase-6-phosphogluconolactonase(Plasmodium falciparum 3D7)
Burnham Center For Chemical Genomics

Curated by PubChem BioAssay
LigandPNGBDBM29643((6aS)-6-methyl-5,6,6a,7-tetrahydro-4H-dibenzo[de,g...)
Affinity DataIC50: >8.00E+4nMAssay Description:Data Source: Sanford-Burnham Center for Chemical Genomics (SBCCG) Source Affiliation: Sanford-Burnham Medical Research Institute (SBMRI, San Diego CA...More data for this Ligand-Target Pair
In DepthDetails PCBioAssay
TargetPolyadenylate-binding protein 1(Homo sapiens (Human))
Burnham Center For Chemical Genomics

Curated by PubChem BioAssay
LigandPNGBDBM29643((6aS)-6-methyl-5,6,6a,7-tetrahydro-4H-dibenzo[de,g...)
Affinity DataIC50: >6.60E+4nMAssay Description:Data Source: Sanford-Burnham Center for Chemical Genomics (SBCCG) Source Affiliation: Sanford-Burnham Medical Research Institute (SBMRI, San Diego, C...More data for this Ligand-Target Pair
In DepthDetails PCBioAssay
TargetD(1A) dopamine receptor(RAT)
Northeastern University

Curated by ChEMBL
LigandPNGBDBM29643((6aS)-6-methyl-5,6,6a,7-tetrahydro-4H-dibenzo[de,g...)
Affinity DataIC50:  3.62E+3nMAssay Description:In vitro binding affinity towards rat Dopamine receptor D1 by [3H]-SCH-23,390 displacement.More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetD(2) dopamine receptor(Rattus norvegicus (rat))
Northeastern University

Curated by ChEMBL
LigandPNGBDBM29643((6aS)-6-methyl-5,6,6a,7-tetrahydro-4H-dibenzo[de,g...)
Affinity DataIC50:  680nMAssay Description:In vitro binding affinity towards rat Dopamine receptor D2 by [3H]-spiperone displacement.More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetE3 ubiquitin-protein ligase Mdm2(Homo sapiens (Human))
Kyoto University

Curated by ChEMBL
LigandPNGBDBM29643((6aS)-6-methyl-5,6,6a,7-tetrahydro-4H-dibenzo[de,g...)
Affinity DataIC50:  175nMAssay Description:Inhibition of biotin-labelled L-p53 binding to L-MDM2 (25 to 109 residues) (unknown origin) by FAM labeled P4 peptide based fluorescence polarization...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetMannose-6-phosphate isomerase(Homo sapiens (Human))
Burnham Center For Chemical Genomics

Curated by PubChem BioAssay
LigandPNGBDBM29643((6aS)-6-methyl-5,6,6a,7-tetrahydro-4H-dibenzo[de,g...)
Affinity DataIC50:  2.49E+4nMpH: 7.4 T: 2°CAssay Description:The purpose of this assay is to identify non-competititve inhibitors of human PMI. This is accomplished by using a G6PD- NADPH-coupled assay. In the ...More data for this Ligand-Target Pair
In DepthDetails PCBioAssay
TargetBcl-2-related protein A1(Homo sapiens (Human))
Nmmlsc

Curated by PubChem BioAssay
LigandPNGBDBM29643((6aS)-6-methyl-5,6,6a,7-tetrahydro-4H-dibenzo[de,g...)
Affinity DataEC50:  1.51E+4nMpH: 7.4 T: 2°CAssay Description:The multiplex is constructed by using beads for each protein target that have been labeled with varying intensities of red color, so that each assay ...More data for this Ligand-Target Pair
In DepthDetails PCBioAssay
TargetRunt-related transcription factor 1(Homo sapiens (Human))
Burnham Center For Chemical Genomics

Curated by PubChem BioAssay
LigandPNGBDBM29643((6aS)-6-methyl-5,6,6a,7-tetrahydro-4H-dibenzo[de,g...)
Affinity DataIC50:  7.12E+3nMpH: 7.4 T: 2°CAssay Description:This assay is to identify inhibitors of the protein-protein interaction between the RUNX1 Runt domain and CBFbeta-SMMHC. This is accomplished by usin...More data for this Ligand-Target Pair
In DepthDetails PCBioAssay
TargetRunt-related transcription factor 1(Homo sapiens (Human))
Burnham Center For Chemical Genomics

Curated by PubChem BioAssay
LigandPNGBDBM29643((6aS)-6-methyl-5,6,6a,7-tetrahydro-4H-dibenzo[de,g...)
Affinity DataIC50:  8.48E+3nMpH: 7.4 T: 2°CAssay Description:This assay is to identify inhibitors of the protein-protein interaction between the RUNX1 Runt domain and CBFbeta-SMMHC. This is accomplished by usin...More data for this Ligand-Target Pair
In DepthDetails PCBioAssay
TargetRunt-related transcription factor 1(Homo sapiens (Human))
Burnham Center For Chemical Genomics

Curated by PubChem BioAssay
LigandPNGBDBM29643((6aS)-6-methyl-5,6,6a,7-tetrahydro-4H-dibenzo[de,g...)
Affinity DataIC50:  1.78E+4nMpH: 7.4 T: 2°CAssay Description:This assay is to identify inhibitors of the protein-protein interaction between the RUNX1 Runt domain and CBFbeta-SMMHC. This is accomplished by usin...More data for this Ligand-Target Pair
In DepthDetails PCBioAssay
TargetIsoform Bcl-X(L) of Bcl-2-like protein 1 (Bcl-xL)(Homo sapiens (Human))
Nmmlsc

Curated by PubChem BioAssay
LigandPNGBDBM29643((6aS)-6-methyl-5,6,6a,7-tetrahydro-4H-dibenzo[de,g...)
Affinity DataEC50:  1.86E+4nMpH: 7.4 T: 2°CAssay Description:The HTS assay was conducted in 384-well microplates in a total assay volume per well of 10.1 microliters (5 microliters of bead mixture, 0.1 microlit...More data for this Ligand-Target Pair
In DepthDetails PCBioAssay
TargetRunt-related transcription factor 1(Homo sapiens (Human))
Burnham Center For Chemical Genomics

Curated by PubChem BioAssay
LigandPNGBDBM29643((6aS)-6-methyl-5,6,6a,7-tetrahydro-4H-dibenzo[de,g...)
Affinity DataIC50:  7.12E+3nMpH: 7.4 T: 2°CAssay Description:This assay is to use HTS to identify inhibitors of the protein-protein interaction between the RUNX1 Runt domain and CBFbeta-SMMHC, a potential thera...More data for this Ligand-Target Pair
In DepthDetails PCBioAssay