BDBM300990 N-(4-((6S,8R)- 7-((1- fluorocyclo- propyl)methyl)-8- methyl- 6,7,8,9- tetrahydro-3H- pyrazolo[4,3- f]isoquinolin- 6-yl)-3- methoxyphenyl)- 1-(3,3,3- trifluoropropyl) azetidin-3- amine::US10131663, Example 56::US10590130, Example 56::US10961241, Example 56

SMILES COc1cc(NC2CN(CCC(F)(F)F)C2)ccc1[C@H]1N(CC2(F)CC2)[C@H](C)Cc2c1ccc1[nH]ncc21

InChI Key InChIKey=RCSMYQHGJMPVOW-UHFFFAOYSA-N

Data  3 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 3 hits for monomerid = 300990   

TargetEstrogen receptor [307-554](Human)
Astrazeneca

US Patent
LigandChemical structure of BindingDB Monomer ID 300990BDBM300990(N-(4-((6S,8R)- 7-((1- fluorocyclo- propyl)methyl)-...)
Affinity DataIC50: 8.20nMAssay Description:The assay was performed as follows with all reagent additions carried out using the Beckman Coulter BioRAPTR FRD microfluidic workstation:1. Acoustic...More data for this Ligand-Target Pair
In Depth
Date in BDB:
10/4/2021
Entry Details
US Patent

LigandChemical structure of BindingDB Monomer ID 300990BDBM300990(N-(4-((6S,8R)- 7-((1- fluorocyclo- propyl)methyl)-...)
Affinity DataIC50: 8.20nMAssay Description:hERG (human ether go go-related gene) potassium channels are essential for normal electrical activity in the heart. Arrhythmia can be induced by a bl...More data for this Ligand-Target Pair
In Depth
Date in BDB:
12/7/2020
Entry Details
US Patent

TargetEstrogen receptor(Human)
Astrazeneca

US Patent
LigandChemical structure of BindingDB Monomer ID 300990BDBM300990(N-(4-((6S,8R)- 7-((1- fluorocyclo- propyl)methyl)-...)
Affinity DataIC50: 8.20nMAssay Description:The assay principle is that ER alpha-LBD (GST) is added to a fluorescent ligand to form a receptor/fluorophore complex. A terbium-labelled anti-GST a...More data for this Ligand-Target Pair
In Depth
Date in BDB:
3/29/2019
Entry Details
US Patent