BDBM301034 4-(2-{[(3aR,5S,6aS)- octahydrocyclopenta[c]pyrrol-5- yl]amino}-5-(4- methylphenyl)pyrimidin-4- yl)benzonitrile::US10131664, Example 27::US10543198, Example 27::US10864202, Example 27

SMILES Cc5ccc(c3cnc(N[C@@H]2C[C@H]1CNC[C@H]1C2)nc3c4ccc(C#N)cc4)cc5

InChI Key InChIKey=KZFZSLOMMLYPNX-UHFFFAOYSA-N

Data  3 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
Find this compound or compounds like it in BindingDB:
   Substructure
Similarity at least:  must be >=0.5
Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 3 hits for monomerid = 301034   

TargetLysine-specific histone demethylase 1A(Human)
Celgene Quanticel Research

US Patent
LigandChemical structure of BindingDB Monomer ID 301034BDBM301034(4-(2-{[(3aR,5S,6aS)- octahydrocyclopenta[c]pyrrol-...)
Affinity DataIC50: 550nMAssay Description:This assay determines the ability of a test compound to inhibit LSD1 demethylase activity. E. coli expressed full-length human LSD1 (Accession number...More data for this Ligand-Target Pair
In Depth
Date in BDB:
11/1/2020
Entry Details
US Patent

TargetLysine-specific histone demethylase 1A(Human)
Celgene Quanticel Research

US Patent
LigandChemical structure of BindingDB Monomer ID 301034BDBM301034(4-(2-{[(3aR,5S,6aS)- octahydrocyclopenta[c]pyrrol-...)
Affinity DataIC50: 550nMAssay Description:The enzymatic assay of LSD1 activity is based on Time Resolved-Fluorescence Resonance Energy Transfer (TR-FRET) detection. The inhibitory properties ...More data for this Ligand-Target Pair
In Depth
Date in BDB:
3/29/2019
Entry Details
US Patent

TargetLysine-specific histone demethylase 1A(Human)
Celgene Quanticel Research

US Patent
LigandChemical structure of BindingDB Monomer ID 301034BDBM301034(4-(2-{[(3aR,5S,6aS)- octahydrocyclopenta[c]pyrrol-...)
Affinity DataIC50: 550nMAssay Description:The enzymatic assay of LSD1 activity is based on Time Resolved-Fluorescence Resonance Energy Transfer (TR-FRET) detection. The inhibitory properties ...More data for this Ligand-Target Pair
In Depth
Date in BDB:
7/18/2021
Entry Details
US Patent