BDBM301117 4-[2-(1,4-diazepan-1-yl)-5-(2- methylindazol-5-yl)pyrimidin-4-yl]-2- fluorobenzonitrile::US10131664, Example 110

SMILES Cn1cc2cc(ccc2n1)-c1cnc(nc1-c1ccc(C#N)c(F)c1)N1CCCNCC1

InChI Key InChIKey=OUSGZXFWFLYBBH-UHFFFAOYSA-N

Data  1 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
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Similarity at least:  must be >=0.5
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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 1 hit for monomerid = 301117   

TargetLysine-specific histone demethylase 1A(Human)
Celgene Quanticel Research

US Patent
LigandChemical structure of BindingDB Monomer ID 301117BDBM301117(4-[2-(1,4-diazepan-1-yl)-5-(2- methylindazol-5-yl)...)
Affinity DataIC50: 10nMAssay Description:The enzymatic assay of LSD1 activity is based on Time Resolved-Fluorescence Resonance Energy Transfer (TR-FRET) detection. The inhibitory properties ...More data for this Ligand-Target Pair
In Depth
Date in BDB:
3/29/2019
Entry Details
US Patent