BDBM302540 N5-(tert-Butyl)-2-(3,4- difluorophenyl)-6,7- dihydropyrazolo[1,5-a]pyrazine- 3,5(4H)-dicarboxamide::US9598423, Example 106

SMILES CC(C)(C)NC(=O)N1CCn2nc(c(C(N)=O)c2C1)-c1ccc(F)c(F)c1

InChI Key InChIKey=ADTUFLPAUZBTOF-UHFFFAOYSA-N

Data  2 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
Find this compound or compounds like it in BindingDB:
   Substructure
Similarity at least:  must be >=0.5
Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 2 hits for monomerid = 302540   

TargetCasein kinase I isoform delta(Human)
Bristol-Myers Squibb

US Patent
LigandChemical structure of BindingDB Monomer ID 302540BDBM302540(N5-(tert-Butyl)-2-(3,4- difluorophenyl)-6,7- dihyd...)
Affinity DataIC50: 10nMAssay Description:The kinase assay was performed in V-bottom 384-well plates. The final assay volume was 30 μl prepared from 15 μl additions of enzyme, subst...More data for this Ligand-Target Pair
In Depth
Date in BDB:
3/29/2019
Entry Details
US Patent

TargetCasein kinase I isoform epsilon(Human)
Bristol-Myers Squibb

US Patent
LigandChemical structure of BindingDB Monomer ID 302540BDBM302540(N5-(tert-Butyl)-2-(3,4- difluorophenyl)-6,7- dihyd...)
Affinity DataIC50: 55nMAssay Description:The kinase assay was performed in V-bottom 384-well plates. The final assay volume was 30 μl prepared from 15 μl additions of enzyme, subst...More data for this Ligand-Target Pair
In Depth
Date in BDB:
3/29/2019
Entry Details
US Patent