BDBM304349 (S)-2-(4-(3-(methylsulfonyl)phenyl)-1-(4-(trifluoromethyl)pyrimidin-2-yl)piperazin-2-yl)propan-2-ol::US10144715, Compound 7-24

SMILES CC(C)(O)[C@@H]1CN(CCN1c1nccc(n1)C(F)(F)F)c1cccc(c1)S(C)(=O)=O

InChI Key InChIKey=DTDSYQPSZOADNN-UHFFFAOYSA-N

Data  2 KI  2 EC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 4 hits for monomerid = 304349   

TargetOxysterols receptor LXR-beta(Human)
Vitae Pharmaceuticals

US Patent
LigandChemical structure of BindingDB Monomer ID 304349BDBM304349((S)-2-(4-(3-(methylsulfonyl)phenyl)-1-(4-(trifluor...)
Affinity DataEC50:  14nMAssay Description:This assay is based on the ability of the LXR-LBDs (LXRα and LXRβ) to recruit and interact with a co-activator peptide. This assay was run ...More data for this Ligand-Target Pair
In Depth
Date in BDB:
3/30/2019
Entry Details
US Patent

TargetOxysterols receptor LXR-beta(Human)
Vitae Pharmaceuticals

US Patent
LigandChemical structure of BindingDB Monomer ID 304349BDBM304349((S)-2-(4-(3-(methylsulfonyl)phenyl)-1-(4-(trifluor...)
Affinity DataKi:  43nMAssay Description:Compounds of the invention were assessed in a competition binding assay where different concentrations of compounds were incubated with the LXR ligan...More data for this Ligand-Target Pair
In Depth
Date in BDB:
3/30/2019
Entry Details
US Patent

TargetOxysterols receptor LXR-alpha(Human)
Vitae Pharmaceuticals

US Patent
LigandChemical structure of BindingDB Monomer ID 304349BDBM304349((S)-2-(4-(3-(methylsulfonyl)phenyl)-1-(4-(trifluor...)
Affinity DataEC50:  457nMAssay Description:This assay is based on the ability of the LXR-LBDs (LXRα and LXRβ) to recruit and interact with a co-activator peptide. This assay was run ...More data for this Ligand-Target Pair
In Depth
Date in BDB:
3/30/2019
Entry Details
US Patent

TargetOxysterols receptor LXR-alpha(Human)
Vitae Pharmaceuticals

US Patent
LigandChemical structure of BindingDB Monomer ID 304349BDBM304349((S)-2-(4-(3-(methylsulfonyl)phenyl)-1-(4-(trifluor...)
Affinity DataKi:  1.03E+3nMAssay Description:Compounds of the invention were assessed in a competition binding assay where different concentrations of compounds were incubated with the LXR ligan...More data for this Ligand-Target Pair
In Depth
Date in BDB:
3/30/2019
Entry Details
US Patent