BDBM313022 N-{2-[(4aR,6S,8aR)-2-amino-6-methyl-4,4a,5,6-tetrahydropyrano[3,4-d][1,3]thiazin-8a(8H)-yl]-1,3-thiazol-4-yl}-3,3-difluorocyclobutanecarboxamide::US10166216, Compound 32::US9605007, Example 78

SMILES Nc1nc(Nc2ccc(OCCN3CCCC3)cc2)nn1-c1ccc(Br)cn1

InChI Key InChIKey=KSAUSDAVZWPCHC-UHFFFAOYSA-N

Data  2 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 2 hits for monomerid = 313022   

TargetBeta-secretase 1(Human)
Pfizer

US Patent
LigandChemical structure of BindingDB Monomer ID 313022BDBM313022(US10166216, Compound 32 | N-{2-[(4aR,6S,8aR)-2-ami...)
Affinity DataIC50: 1.49E+3nMAssay Description:Beta-secretase (BACE) is one of the enzymes involved in the generation of the amyloid beta peptide found in the amyloid plaques of Alzheimer's Di...More data for this Ligand-Target Pair
In Depth
Date in BDB:
4/24/2019
Entry Details
US Patent

TargetTyrosine-protein kinase receptor UFO(Human)
Rigel Pharmaceuticals

US Patent
LigandChemical structure of BindingDB Monomer ID 313022BDBM313022(US10166216, Compound 32 | N-{2-[(4aR,6S,8aR)-2-ami...)
Affinity DataIC50: 2.00E+4nMAssay Description:The resulting chemiluminescence was read with a Luminomitor within 10 minutes to minimize changes in signal intensity. After reading the chemilumines...More data for this Ligand-Target Pair
In Depth
Date in BDB:
4/24/2019
Entry Details
US Patent