BDBM315271 1-Methyl-3-{1-[5- methyl-2-(4- trifluoromethyl-phenyl)- thiazol-4-ylmethyl]- piperidin-4-yl}-1,3- dihydro-benzoimidazol- 2-one::US10172843, Example 5

SMILES Cc1sc(nc1CN1CCC(CC1)n1c2ccccc2n(C)c1=O)-c1ccc(cc1)C(F)(F)F

InChI Key InChIKey=BOFFSKFLQXGWQM-UHFFFAOYSA-N

Data  1 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 1 hit for monomerid = 315271   

TargetCathepsin S(Human)
Hoffmann-La Roche

US Patent
LigandChemical structure of BindingDB Monomer ID 315271BDBM315271(US10172843, Example 5 | 1-Methyl-3-{1-[5- methyl-2...)
Affinity DataIC50: 2.05E+3nMAssay Description:Enzyme activity is measured by observing the increase in fluorescence intensity caused by cleavage of a peptide substrate containing a fluorophore wh...More data for this Ligand-Target Pair
In Depth
Date in BDB:
4/30/2019
Entry Details
US Patent