BDBM320019 Trans Isomer 1; 3- (5-chloro-1,3- thiazol-2-yl)-5-{[3- hydroxybutan-2- yl]oxy}-N-{(1R)-1- [6-(trifluoromethyl) pyridin-3-yl]ethyl} benzamide::US10174016, Example 186::US10174016, Example 189::US10202369, Example 189::US10472354, Example 189

SMILES CC(O)C(C)Oc1cc(cc(c1)-c1ncc(Cl)s1)C(=O)N[C@H](C)c1ccc(nc1)C(F)(F)F

InChI Key InChIKey=HTVWJAQZHONFAU-UHFFFAOYSA-N

Data  16 IC50

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 16 hits for monomerid = 320019   

TargetP2X purinoceptor 3(Human)
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US Patent

LigandBDBM320019(US10174016, Example 186 | Trans Isomer 1; 3- (5-ch...)Copy SMILESCopy InChI

Affinity DataIC50: 8nMAssay Description:A fluorescent imaging plate reader (FLEX/FLIPR station; Molecular Devices) was used to monitor intracellular calcium levels using the calcium-chelati...More data for this Ligand-Target Pair

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Date in BDB:
9/2/2019
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TargetP2X purinoceptor 3(Human)
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LigandBDBM320019(US10174016, Example 186 | Trans Isomer 1; 3- (5-ch...)Copy SMILESCopy InChI

Affinity DataIC50: 8nMAssay Description:A fluorescent imaging plate reader (FLEX/FLIPR station; Molecular Devices) was used to monitor intracellular calcium levels using the calcium-chelati...More data for this Ligand-Target Pair

Target InfoPDBKEGG
UniProtKB/SwissProt
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Ligand InfoPC cidPC sidSimilars

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Date in BDB:
5/15/2019
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TargetP2X purinoceptor 3(Human)
Bayer Aktiengesellschaft

US Patent

LigandBDBM320019(US10174016, Example 186 | Trans Isomer 1; 3- (5-ch...)Copy SMILESCopy InChI

Affinity DataIC50: 8nMAssay Description:A fluorescent imaging plate reader (FILEX/FLIPR station; Molecular Devices) was used to monitor intracellular calcium levels using the calcium-chelat...More data for this Ligand-Target Pair

Target InfoPDBKEGG
UniProtKB/SwissProt
GoogleScholar

Ligand InfoPC cidPC sidSimilars

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Date in BDB:
9/14/2020
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TargetP2X purinoceptor 3(Human)
Bayer Aktiengesellschaft

US Patent

LigandBDBM320019(US10174016, Example 186 | Trans Isomer 1; 3- (5-ch...)Copy SMILESCopy InChI

Affinity DataIC50: 8nMAssay Description:A fluorescent imaging plate reader (FLEX/FLIPR station; Molecular Devices) was used to monitor intracellular calcium levels using the calcium-chelati...More data for this Ligand-Target Pair

Target InfoPDBKEGG
UniProtKB/SwissProt
GoogleScholar

Ligand InfoPC cidPC sidSimilars

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Date in BDB:
5/16/2019
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TargetP2X purinoceptor 3(Human)
Bayer Aktiengesellschaft

US Patent

LigandBDBM320019(US10174016, Example 186 | Trans Isomer 1; 3- (5-ch...)Copy SMILESCopy InChI

Affinity DataIC50: 10nMAssay Description:A fluorescent imaging plate reader (FLEX/FLIPR station; Molecular Devices) was used to monitor intracellular calcium levels using the calcium-chelati...More data for this Ligand-Target Pair

Target InfoPDBKEGG
UniProtKB/SwissProt
GoogleScholar

Ligand InfoPC cidPC sidSimilars

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Date in BDB:
5/15/2019
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TargetP2X purinoceptor 3(Human)
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US Patent

LigandBDBM320019(US10174016, Example 186 | Trans Isomer 1; 3- (5-ch...)Copy SMILESCopy InChI

Affinity DataIC50: 10nMAssay Description:A fluorescent imaging plate reader (FILEX/FLIPR station; Molecular Devices) was used to monitor intracellular calcium levels using the calcium-chelat...More data for this Ligand-Target Pair

Target InfoPDBKEGG
UniProtKB/SwissProt
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Ligand InfoPC cidPC sidSimilars

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Date in BDB:
9/14/2020
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TargetP2X purinoceptor 3(Human)
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US Patent

LigandBDBM320019(US10174016, Example 186 | Trans Isomer 1; 3- (5-ch...)Copy SMILESCopy InChI

Affinity DataIC50: 10nMAssay Description:A fluorescent imaging plate reader (FLEX/FLIPR station; Molecular Devices) was used to monitor intracellular calcium levels using the calcium-chelati...More data for this Ligand-Target Pair

Target InfoPDBKEGG
UniProtKB/SwissProt
GoogleScholar

Ligand InfoPC cidPC sidSimilars

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Date in BDB:
5/16/2019
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TargetP2X purinoceptor 3(Human)
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US Patent

LigandBDBM320019(US10174016, Example 186 | Trans Isomer 1; 3- (5-ch...)Copy SMILESCopy InChI

Affinity DataIC50: 10nMAssay Description:A fluorescent imaging plate reader (FLEX/FLIPR station; Molecular Devices) was used to monitor intracellular calcium levels using the calcium-chelati...More data for this Ligand-Target Pair

Target InfoPDBKEGG
UniProtKB/SwissProt
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Date in BDB:
9/2/2019
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TargetP2X purinoceptor 2(Human)
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LigandBDBM320019(US10174016, Example 186 | Trans Isomer 1; 3- (5-ch...)Copy SMILESCopy InChI

Affinity DataIC50: 247nMAssay Description:A fluorescent imaging plate reader (FLEX/FLIPR station; Molecular Devices) was used to monitor intracellular calcium levels using the calcium-chelati...More data for this Ligand-Target Pair

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Date in BDB:
5/15/2019
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TargetP2X purinoceptor 2(Human)
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US Patent

LigandBDBM320019(US10174016, Example 186 | Trans Isomer 1; 3- (5-ch...)Copy SMILESCopy InChI

Affinity DataIC50: 247nMAssay Description:A fluorescent imaging plate reader (FLEX/FLIPR station; Molecular Devices) was used to monitor intracellular calcium levels using the calcium-chelati...More data for this Ligand-Target Pair

Target InfoPDB
UniProtKB/SwissProt
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Ligand InfoPC cidPC sidSimilars

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Date in BDB:
5/16/2019
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TargetP2X purinoceptor 2/3(Human)
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LigandBDBM320019(US10174016, Example 186 | Trans Isomer 1; 3- (5-ch...)Copy SMILESCopy InChI

Affinity DataIC50: 247nMAssay Description:A fluorescent imaging plate reader (FILEX/FLIPR station; Molecular Devices) was used to monitor intracellular calcium levels using the calcium-chelat...More data for this Ligand-Target Pair

Target InfoPDBKEGG
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Ligand InfoPC cidPC sidSimilars

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Date in BDB:
9/14/2020
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TargetP2X purinoceptor 2/3(Human)
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US Patent

LigandBDBM320019(US10174016, Example 186 | Trans Isomer 1; 3- (5-ch...)Copy SMILESCopy InChI

Affinity DataIC50: 247nMAssay Description:A fluorescent imaging plate reader (FLEX/FLIPR station; Molecular Devices) was used to monitor intracellular calcium levels using the calcium-chelati...More data for this Ligand-Target Pair

Target InfoPDBKEGG
UniProtKB/SwissProt
GoogleScholar

Ligand InfoPC cidPC sidSimilars

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Date in BDB:
9/2/2019
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TargetP2X purinoceptor 2/3(Human)
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US Patent

LigandBDBM320019(US10174016, Example 186 | Trans Isomer 1; 3- (5-ch...)Copy SMILESCopy InChI

Affinity DataIC50: 258nMAssay Description:A fluorescent imaging plate reader (FLEX/FLIPR station; Molecular Devices) was used to monitor intracellular calcium levels using the calcium-chelati...More data for this Ligand-Target Pair

Target InfoPDBKEGG
UniProtKB/SwissProt
GoogleScholar

Ligand InfoPC cidPC sidSimilars

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Date in BDB:
9/2/2019
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TargetP2X purinoceptor 2(Human)
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US Patent

LigandBDBM320019(US10174016, Example 186 | Trans Isomer 1; 3- (5-ch...)Copy SMILESCopy InChI

Affinity DataIC50: 258nMAssay Description:A fluorescent imaging plate reader (FLEX/FLIPR station; Molecular Devices) was used to monitor intracellular calcium levels using the calcium-chelati...More data for this Ligand-Target Pair

Target InfoPDB
UniProtKB/SwissProt
GoogleScholar

Ligand InfoPC cidPC sidSimilars

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Date in BDB:
5/15/2019
Entry Details
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TargetP2X purinoceptor 2(Human)
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US Patent

LigandBDBM320019(US10174016, Example 186 | Trans Isomer 1; 3- (5-ch...)Copy SMILESCopy InChI

Affinity DataIC50: 258nMAssay Description:A fluorescent imaging plate reader (FLEX/FLIPR station; Molecular Devices) was used to monitor intracellular calcium levels using the calcium-chelati...More data for this Ligand-Target Pair

Target InfoPDB
UniProtKB/SwissProt
GoogleScholar

Ligand InfoPC cidPC sidSimilars

In Depth
Date in BDB:
5/16/2019
Entry Details
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TargetP2X purinoceptor 2/3(Human)
Bayer Aktiengesellschaft

US Patent

LigandBDBM320019(US10174016, Example 186 | Trans Isomer 1; 3- (5-ch...)Copy SMILESCopy InChI

Affinity DataIC50: 258nMAssay Description:A fluorescent imaging plate reader (FILEX/FLIPR station; Molecular Devices) was used to monitor intracellular calcium levels using the calcium-chelat...More data for this Ligand-Target Pair

Target InfoPDBKEGG
UniProtKB/SwissProt
GoogleScholar

Ligand InfoPC cidPC sidSimilars

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Date in BDB:
9/14/2020
Entry Details
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