BDBM320946 (R)- or (S)-1- (Cyclopropyl(4-(1,1- difluoroethyl)-3- fluorophenyl)methyl)- 6-(dimethylamino)-3- (hydroxymethyl)-1H- pyrazolo[3,4- d]pyrimidin-4(5H)-one::US10174037, Example 350::US10174037, Example 351

SMILES CN(C)c1nc2c(c(CO)nn2C(c2ccc(C(C)(F)F)c(F)c2)C2CC2)c(=O)[nH]1

InChI Key InChIKey=QNGPJJNFOIDJQG-UHFFFAOYSA-N

Data  2 KI

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 2 hits for monomerid = 320946   

TargetcGMP-dependent 3',5'-cyclic phosphodiesterase(Human)
Merck Sharp & Dohme

US Patent
LigandChemical structure of BindingDB Monomer ID 320946BDBM320946(US10174037, Example 351 | (R)- or (S)-1- (Cyclopro...)
Affinity DataKi:  0.0200nMAssay Description:Performed by Lab B. The activity of the compounds in accordance with the present invention as PDE2 inhibitors may be readily determined using a fluor...More data for this Ligand-Target Pair
In Depth
Date in BDB:
5/16/2019
Entry Details
US Patent

TargetcGMP-dependent 3',5'-cyclic phosphodiesterase(Human)
Merck Sharp & Dohme

US Patent
LigandChemical structure of BindingDB Monomer ID 320946BDBM320946(US10174037, Example 351 | (R)- or (S)-1- (Cyclopro...)
Affinity DataKi:  0.140nMAssay Description:Performed by Lab B. The activity of the compounds in accordance with the present invention as PDE2 inhibitors may be readily determined using a fluor...More data for this Ligand-Target Pair
In Depth
Date in BDB:
5/16/2019
Entry Details
US Patent