BDBM328001 N-(1-(4- cyanobenzyl)piperidin-4- yl)-5-(4-(fluoro(4- fluorophenyl)methyl) piperidine-1- carbonyl)picolinamide::US10377742, Compound 138::US9663496, Compound 138

SMILES FC(C1CCN(CC1)C(=O)c1ccc(nc1)C(=O)NC1CCN(Cc2ccc(cc2)C#N)CC1)c1ccc(F)cc1

InChI Key InChIKey=FJNHSBVZTQFKEF-UHFFFAOYSA-N

Data  1 IC50  2 EC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
Find this compound or compounds like it in BindingDB:
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Similarity at least:  must be >=0.5
Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 3 hits for monomerid = 328001   

Target5'-AMP-activated protein kinase catalytic subunit alpha-2(Homo sapiens (Human))
Rigel Pharmaceuticals

US Patent
LigandPNGBDBM328001(N-(1-(4- cyanobenzyl)piperidin-4- yl)-5-(4-(fluoro...)
Affinity DataEC50: <500nMAssay Description:Compounds were assayed for their ability to activate AMPK using an enzyme-linked immunosorbent assay. Reagents and procedures for measuring AMPK acti...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent
TargetCytochrome P450 3A4(Homo sapiens (Human))
Rigel Pharmaceuticals

Curated by ChEMBL
LigandPNGBDBM328001(N-(1-(4- cyanobenzyl)piperidin-4- yl)-5-(4-(fluoro...)
Affinity DataIC50:  9.80E+3nMAssay Description:Inhibition of CYP3A4 (unknown origin) in presence of NADPHMore data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails PubMed
Target5'-AMP-activated protein kinase catalytic subunit alpha-2(Homo sapiens (Human))
Rigel Pharmaceuticals

US Patent
LigandPNGBDBM328001(N-(1-(4- cyanobenzyl)piperidin-4- yl)-5-(4-(fluoro...)
Affinity DataEC50: <500nMAssay Description:Compounds were assayed for their ability to activate AMPK using an enzyme-linked immunosorbent assay. Reagents and procedures for measuring AMPK acti...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent