BDBM332081 US10189854, Compound 34::US10189854, Compound 94::[1-[5-(2-Fluorophenyl)-pyrimidin-2-yl]-spiro[1,2-dihydro-indole-3,1''-cyclopropane]-6-yl]-[4-(2-hydroxy-ethyl)-piperazin-1-yl]-methanone

SMILES OCCN1CCN(CC1)C(=O)c1ccc2c(c1)N(CC21CC1)c1ncc(cn1)-c1ccccc1F

InChI Key InChIKey=OYEVYMWYNUSNIX-UHFFFAOYSA-N

Data  2 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 2 hits for monomerid = 332081   

TargetcAMP-specific 3',5'-cyclic phosphodiesterase 4B(Human)
Gruenenthal

US Patent
LigandChemical structure of BindingDB Monomer ID 332081BDBM332081(US10189854, Compound 34 | [1-[5-(2-Fluorophenyl)-p...)
Affinity DataIC50: 100nMAssay Description:The inhibiting effect of the compounds on the enzyme activity of human PDE4B1 was measured by the quantification of 5′-adenosine monophosphate ...More data for this Ligand-Target Pair
In Depth
Date in BDB:
6/12/2019
Entry Details
US Patent

TargetcAMP-specific 3',5'-cyclic phosphodiesterase 4B(Human)
Gruenenthal

US Patent
LigandChemical structure of BindingDB Monomer ID 332081BDBM332081(US10189854, Compound 34 | [1-[5-(2-Fluorophenyl)-p...)
Affinity DataIC50: 100nMAssay Description:The inhibiting effect of the compounds on the enzyme activity of human PDE4B1 was measured by the quantification of 5′-adenosine monophosphate ...More data for this Ligand-Target Pair
In Depth
Date in BDB:
6/12/2019
Entry Details
US Patent