BDBM332704 US10196378, Compound C07

SMILES CN1CCN(Cc2ccc(NC(=O)Nc3ccc(Oc4ccc5ccccc5c4)cc3)cc2C(F)(F)F)CC1

InChI Key InChIKey=DALOQNGTFFDAFY-UHFFFAOYSA-N

Data  5 KI

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
Find this compound or compounds like it in BindingDB:
   Substructure
Similarity at least:  must be >=0.5
Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 5 hits for monomerid = 332704   

TargetTyrosine-protein kinase ABL1 [T315I](Homo sapiens (Human))
The Regents of The University of Michigan

US Patent
LigandPNGBDBM332704(US10196378, Compound C07)
Affinity DataKi:  119nMAssay Description:The biochemical assays were carried out using the non-phosphorylated kinase domain of c-Abl, Bcr-Abl in Ba/F3 cells is in the phosphorylated state.More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent
TargetTyrosine-protein kinase ABL1(Homo sapiens (Human))
The Regents of The University of Michigan

US Patent
LigandPNGBDBM332704(US10196378, Compound C07)
Affinity DataKi:  155nMAssay Description:The biochemical assays were carried out using the non-phosphorylated kinase domain of c-Abl, Bcr-Abl in Ba/F3 cells is in the phosphorylated state.More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent
TargetTyrosine-protein kinase ABL1(Homo sapiens (Human))
The Regents of The University of Michigan

US Patent
LigandPNGBDBM332704(US10196378, Compound C07)
Affinity DataKi:  155nMAssay Description:The biochemical assays were carried out using the non-phosphorylated kinase domain of c-Abl, Bcr-Abl in Ba/F3 cells is in the phosphorylated state.More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent
TargetTyrosine-protein kinase ABL1 [Y253F](Homo sapiens (Human))
The Regents of The University of Michigan

US Patent
LigandPNGBDBM332704(US10196378, Compound C07)
Affinity DataKi: >9.00E+3nMAssay Description:The biochemical assays were carried out using the non-phosphorylated kinase domain of c-Abl, Bcr-Abl in Ba/F3 cells is in the phosphorylated state.More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent
TargetProto-oncogene tyrosine-protein kinase Src(Homo sapiens (Human))
The Regents of The University of Michigan

US Patent
LigandPNGBDBM332704(US10196378, Compound C07)
Affinity DataKi: >2.70E+4nMAssay Description:The biochemical assays were carried out using the non-phosphorylated kinase domain of c-Abl, Bcr-Abl in Ba/F3 cells is in the phosphorylated state.More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent