BDBM33395 2,4-diaminofuro[2,3-d]pyrimidine, 1b::Z-isomer

SMILES COc1ccccc1\C(C)=C/c1coc2nc(N)nc(N)c12

InChI Key InChIKey=JXICVPBZQSPDOK-CLFYSBASSA-N

Data  8 IC50

PDB links: 1 PDB ID matches this monomer.

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
Find this compound or compounds like it in BindingDB:
   Substructure
Similarity at least:  must be >=0.5
Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 8 hits for monomerid = 33395   

TargetEpidermal growth factor receptor(Homo sapiens (Human))
Duquesne University

LigandPNGBDBM33395(2,4-diaminofuro[2,3-d]pyrimidine, 1b | Z-isomer)
Affinity DataIC50: >2.00E+5nMpH: 7.4 T: 2°CAssay Description:Cells used were tumor cell lines naturally expressing high levels of tyrosine kinases. Expression levels at the RNA level were derived from the NCI D...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetVascular endothelial growth factor receptor 2(Homo sapiens (Human))
Duquesne University

LigandPNGBDBM33395(2,4-diaminofuro[2,3-d]pyrimidine, 1b | Z-isomer)
Affinity DataIC50:  1.52E+5nMpH: 7.4 T: 2°CAssay Description:Cells used were tumor cell lines naturally expressing high levels of tyrosine kinases. Expression levels at the RNA level were derived from the NCI D...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetPlatelet-derived growth factor receptor beta(Homo sapiens (Human))
Duquesne University

LigandPNGBDBM33395(2,4-diaminofuro[2,3-d]pyrimidine, 1b | Z-isomer)
Affinity DataIC50:  3.03E+4nMAssay Description:Cells used were tumor cell lines naturally expressing high levels of tyrosine kinases. Expression levels at the RNA level were derived from the NCI D...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetDihydrofolate reductase(Pneumocystis carinii)
Duquesne University

LigandPNGBDBM33395(2,4-diaminofuro[2,3-d]pyrimidine, 1b | Z-isomer)
Affinity DataIC50:  3.00E+4nMAssay Description:Standard DHFR assays were conducted at 37 deg C with continuous recording of change of OD at 340 nm. All determinations of IC50 were made by fitting ...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetDihydrofolate reductase(Homo sapiens (Human))
Duquesne University

LigandPNGBDBM33395(2,4-diaminofuro[2,3-d]pyrimidine, 1b | Z-isomer)
Affinity DataIC50:  1.90E+3nMAssay Description:Standard DHFR assays were conducted at 37 deg C with continuous recording of change of OD at 340 nm. All determinations of IC50 were made by fitting ...More data for this Ligand-Target Pair
TargetDihydrofolate reductase(Rattus norvegicus (rat))
Duquesne University

LigandPNGBDBM33395(2,4-diaminofuro[2,3-d]pyrimidine, 1b | Z-isomer)
Affinity DataIC50:  1.02E+4nMAssay Description:Standard DHFR assays were conducted at 37 deg C with continuous recording of change of OD at 340 nm. All determinations of IC50 were made by fitting ...More data for this Ligand-Target Pair
TargetDihydrofolate reductase(Mus musculus (Mouse))
Duquesne University

LigandPNGBDBM33395(2,4-diaminofuro[2,3-d]pyrimidine, 1b | Z-isomer)
Affinity DataIC50:  3.90E+3nMAssay Description:Standard DHFR assays were conducted at 37 deg C with continuous recording of change of OD at 340 nm. All determinations of IC50 were made by fitting ...More data for this Ligand-Target Pair
TargetBifunctional dihydrofolate reductase-thymidylate synthase(Toxoplasma gondii)
Duquesne University

LigandPNGBDBM33395(2,4-diaminofuro[2,3-d]pyrimidine, 1b | Z-isomer)
Affinity DataIC50:  3.94E+3nMAssay Description:Standard DHFR assays were conducted at 37 deg C with continuous recording of change of OD at 340 nm. All determinations of IC50 were made by fitting ...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed