BDBM341382 1-(5-(4-cyclopropyl-2-fluorophenyl)-2-methyl-7,8-dihydro-[1,3,4]thiadiazolo[2',3':2,3]imidazo[4,5-c]pyridin-6(5H)-yl)-2-((2-ethyl-6-methylpyridin-3-yl)oxy)ethanone::US9765092, Example 1.6.8

SMILES CCc1nc(C)ccc1OCC(=O)N1CCc2nc3sc(C)nn3c2C1c1ccc(cc1F)C1CC1

InChI Key InChIKey=UXQUQNIMZORKCX-UHFFFAOYSA-N

Data  1 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 1 hit for monomerid = 341382   

TargetTryptophan 5-hydroxylase 1(Human)
Actelion Pharmaceuticals

US Patent
LigandChemical structure of BindingDB Monomer ID 341382BDBM341382(US9765092, Example 1.6.8 | 1-(5-(4-cyclopropyl-2-f...)
Affinity DataIC50: 23nMAssay Description:To generate the enzyme, full length human TPH1 is cloned into the plasmid pET20b(+) (Novagen) and expressed in E. coli. The bacterial cells are ruptu...More data for this Ligand-Target Pair
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Date in BDB:
7/29/2019
Entry Details
US Patent