BDBM347738 (rac)-4-[[3-[1-(1-Methylpyrazole-4-carbonyl)piperidin-3-yl]-1H-pyrazol-4-yl]oxy]benzonitrile::US9790217, 63

SMILES Cn1cc(cn1)C(=O)N1CCCC(C1)c1[nH]ncc1Oc1ccc(cc1)C#N

InChI Key InChIKey=YRXFCKNZYREYLP-UHFFFAOYSA-N

Data  2 EC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
Find this compound or compounds like it in BindingDB:
   Substructure
Similarity at least:  must be >=0.5
Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 2 hits for monomerid = 347738   

TargetCytochrome P450 11B2, mitochondrial(Human)
Hoffmann-La Roche

US Patent
LigandChemical structure of BindingDB Monomer ID 347738BDBM347738((rac)-4-[[3-[1-(1-Methylpyrazole-4-carbonyl)piperi...)
Affinity DataEC50:  0.150nMAssay Description:G-402 cells can be obtained from ATCC (CRL-1440) and were originally derived from a renal leiomyoblastoma.The expression plasmids contains the ORF fo...More data for this Ligand-Target Pair
In Depth
Date in BDB:
9/9/2019
Entry Details
US Patent

TargetCytochrome P450 11B1, mitochondrial(Human)
Hoffmann-La Roche

US Patent
LigandChemical structure of BindingDB Monomer ID 347738BDBM347738((rac)-4-[[3-[1-(1-Methylpyrazole-4-carbonyl)piperi...)
Affinity DataEC50:  6.47nMAssay Description:G-402 cells can be obtained from ATCC (CRL-1440) and were originally derived from a renal leiomyoblastoma.The expression plasmids contains the ORF fo...More data for this Ligand-Target Pair
In Depth
Date in BDB:
9/9/2019
Entry Details
US Patent