BDBM352157 4-[(3S,5R)-3-Amino-5-methylpiperidin-1-yl]-N-{[6-(2,6-difluorophenyl)-5-fluoropyridin-2-yl]methyl}-6,7-dihydro-5H-cyclopenta[b]pyridin-3-amine::US9802918, Example 89

SMILES C[C@@H]1C[C@H](N)CN(c2c(NCc3ccc(F)c(-c4c(F)cccc4F)n3)cnc3c2CCC3)C1

InChI Key InChIKey=ZYXFENXGULFJCZ-UHFFFAOYSA-N

Data  3 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
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Similarity at least:  must be >=0.5
Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 3 hits for monomerid = 352157   

TargetSerine/threonine-protein kinase pim-3(Human)
Incyte

US Patent
LigandChemical structure of BindingDB Monomer ID 352157BDBM352157(US9802918, Example 89 | 4-[(3S,5R)-3-Amino-5-methy...)
Affinity DataIC50: 10nMAssay Description:Pim-1 and Pim-3 kinase assays-20 μL reactions were run in white 384 well polystyrene plates dotted with 0.8 μL compound/DMSO in the assay b...More data for this Ligand-Target Pair
In Depth
Date in BDB:
10/1/2019
Entry Details
US Patent

TargetSerine/threonine-protein kinase pim-1(Human)
Incyte

US Patent
LigandChemical structure of BindingDB Monomer ID 352157BDBM352157(US9802918, Example 89 | 4-[(3S,5R)-3-Amino-5-methy...)
Affinity DataIC50: 10nMAssay Description:Pim-1 and Pim-3 kinase assays-20 μL reactions were run in white 384 well polystyrene plates dotted with 0.8 μL compound/DMSO in the assay b...More data for this Ligand-Target Pair
In Depth
Date in BDB:
10/1/2019
Entry Details
US Patent

TargetSerine/threonine-protein kinase pim-2(Human)
Incyte

US Patent
LigandChemical structure of BindingDB Monomer ID 352157BDBM352157(US9802918, Example 89 | 4-[(3S,5R)-3-Amino-5-methy...)
Affinity DataIC50: 550nMAssay Description:Pim-1 and Pim-3 kinase assays-20 μL reactions were run in white 384 well polystyrene plates dotted with 0.8 μL compound/DMSO in the assay b...More data for this Ligand-Target Pair
In Depth
Date in BDB:
10/1/2019
Entry Details
US Patent