BDBM354842 Preparation of 5-chloro-1-(cyclopropylmethyl)-6-(3,4,5-trimethoxyphenyl)-1H-imidazo[4,5-b]pyrazin-2(3H)-one::US10485800, Example 119::US9814704, Example 119

SMILES COc1cc(cc(OC)c1OC)-c1nc2n(CC3CC3)c(=O)[nH]c2nc1Cl

InChI Key InChIKey=RKUCGDPUOWGALR-UHFFFAOYSA-N

Data  2 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
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Similarity at least:  must be >=0.5
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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 2 hits for monomerid = 354842   

TargetMitogen-activated protein kinase kinase kinase 11(Human)
The University of Rochester

US Patent
LigandChemical structure of BindingDB Monomer ID 354842BDBM354842(US9814704, Example 119 | Preparation of 5-chloro-1...)
Affinity DataIC50: 1.00E+3nMAssay Description:200 ng (130 nM) MLK3 (Dundee, DU8313) was incubated with 1 μM inactive MKK7b (Dundee, DU703) in the presence of 2 μM cold ATP (Km) and 0.5 ...More data for this Ligand-Target Pair
In Depth
Date in BDB:
10/13/2019
Entry Details
US Patent

TargetMitogen-activated protein kinase kinase kinase 11(Human)
The University of Rochester

US Patent
LigandChemical structure of BindingDB Monomer ID 354842BDBM354842(US9814704, Example 119 | Preparation of 5-chloro-1...)
Affinity DataIC50: 1.00E+3nMAssay Description:200 ng (130 nM) MLK3 (Dundee, DU8313) was incubated with 1 μM inactive MKK7b (Dundee, DU703) in the presence of 2 μM cold ATP (Km) and 0.5 ...More data for this Ligand-Target Pair
In Depth
Date in BDB:
9/20/2020
Entry Details
US Patent