BDBM35643 pyrimidylpyrrole, 9b

SMILES Cc1ccccc1Nc1ncc(C)c(n1)-c1c[nH]c(c1)C(=O)N[C@H](CO)c1ccccc1

InChI Key InChIKey=CRTYIBGQZSHPSN-JOCHJYFZSA-N

Data  4 KI

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 4 hits for monomerid = 35643   

TargetMitogen-activated protein kinase 1(Human)
Vertex Pharmaceuticals

LigandPNGBDBM35643(pyrimidylpyrrole, 9b)
Affinity DataKi: <2nM ΔG°: <-12.1kcal/molepH: 7.5 T: 30°CAssay Description:A coupled spectrophotometric assay was used in which ADP generated by kinase was converted to ATP with the concomitant production of pyruvate from PE...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed

TargetCyclin-A2/Cyclin-dependent kinase 2(Human)
Vertex Pharmaceuticals

LigandPNGBDBM35643(pyrimidylpyrrole, 9b)
Affinity DataKi:  140nMAssay Description:A coupled spectrophotometric assay was used in which ADP generated by kinase was converted to ATP with the concomitant production of pyruvate from PE...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed

TargetGlycogen synthase kinase-3 beta(Human)
Vertex Pharmaceuticals

LigandPNGBDBM35643(pyrimidylpyrrole, 9b)
Affinity DataKi:  330nMAssay Description:A coupled spectrophotometric assay was used in which ADP generated by kinase was converted to ATP with the concomitant production of pyruvate from PE...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed

TargetAurora kinase A(Human)
Vertex Pharmaceuticals

LigandPNGBDBM35643(pyrimidylpyrrole, 9b)
Affinity DataKi:  860nMAssay Description:A coupled spectrophotometric assay was used in which ADP generated by kinase was converted to ATP with the concomitant production of pyruvate from PE...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed