BDBM35733 sulfonamide deriv., 7a

SMILES NS(=O)(=O)c1ccc(NC(=O)Cc2ccccc2)cc1

InChI Key InChIKey=JWDLYKTZCRIGNW-UHFFFAOYSA-N

Data  17 KI

PDB links: 1 PDB ID matches this monomer.

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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 17 hits for monomerid = 35733   

TargetCarbonic anhydrase 7(Human)
Istanbul University

Curated by ChEMBL
LigandPNGBDBM35733(sulfonamide deriv., 7a)
Affinity DataKi:  4.70nMAssay Description:Inhibition of human recombinant carbonic anhydrase 7 by stopped flow CO2 hydration methodMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed

TargetCarbonic anhydrase 5A, mitochondrial(Human)
Istanbul University

LigandPNGBDBM35733(sulfonamide deriv., 7a)
Affinity DataKi:  6.70nM ΔG°:  -11.1kcal/moleT: 25°CAssay Description:An SX.18MV-R Applied Photophysics (Oxford, UK) stopped-flow instrument has been used to assay the catalytic/inhibition of various CA isozymes. Phenol...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed

TargetCarbonic anhydrase 1(Human)
The Hebrew University of Jerusalem

Curated by ChEMBL
LigandPNGBDBM35733(sulfonamide deriv., 7a)
Affinity DataKi:  7.60nMAssay Description:Inhibition of human carbonic anhydrase 1 preincubated with compound for 15 mins by carbon dioxide hydration assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed

TargetCarbonic anhydrase 5B, mitochondrial(Human)
Istanbul University

LigandPNGBDBM35733(sulfonamide deriv., 7a)
Affinity DataKi:  7.90nM ΔG°:  -11.0kcal/moleT: 25°CAssay Description:An SX.18MV-R Applied Photophysics (Oxford, UK) stopped-flow instrument has been used to assay the catalytic/inhibition of various CA isozymes. Phenol...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed

TargetCarbonic anhydrase 2(Human)
The Hebrew University of Jerusalem

Curated by ChEMBL
LigandPNGBDBM35733(sulfonamide deriv., 7a)
Affinity DataKi:  9nMAssay Description:Inhibition of human carbonic anhydrase 2 preincubated with compound for 15 mins by carbon dioxide hydration assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMedPDB3D3D Structure (crystal)

TargetCarbonic anhydrase 5B, mitochondrial(Human)
Istanbul University

LigandPNGBDBM35733(sulfonamide deriv., 7a)
Affinity DataKi:  10nMAssay Description:Inhibition of human CA5B by stopped-flow CO2 hydrase assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed

TargetCarbonic anhydrase 5A, mitochondrial(Human)
Istanbul University

LigandPNGBDBM35733(sulfonamide deriv., 7a)
Affinity DataKi:  13nMAssay Description:Inhibition of human CA5A by stopped-flow CO2 hydrase assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed

TargetCarbonic anhydrase 14(Human)
The Hebrew University of Jerusalem

Curated by ChEMBL
LigandPNGBDBM35733(sulfonamide deriv., 7a)
Affinity DataKi:  46nMAssay Description:Inhibition of human carbonic anhydrase 14 preincubated with compound for 15 mins by carbon dioxide hydration assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed

TargetCarbonic anhydrase 7(Human)
Istanbul University

Curated by ChEMBL
LigandPNGBDBM35733(sulfonamide deriv., 7a)
Affinity DataKi:  52nMAssay Description:Inhibition of human carbonic anhydrase 7 preincubated with compound for 15 mins by carbon dioxide hydration assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed

TargetCarbonic anhydrase 12(Human)
Universita Degli Studi Di Firenze

Curated by ChEMBL
LigandPNGBDBM35733(sulfonamide deriv., 7a)
Affinity DataKi:  71nMAssay Description:Inhibition of human CA12 by stopped-flow CO2 hydrase assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed

TargetCarbonic anhydrase 12(Human)
Universita Degli Studi Di Firenze

Curated by ChEMBL
LigandPNGBDBM35733(sulfonamide deriv., 7a)
Affinity DataKi:  71nMAssay Description:Inhibition of human carbonic anhydrase-12 by stopped flow CO2 hydrase assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed

TargetCarbonic anhydrase 9(Human)
University of Florida

Curated by ChEMBL
LigandPNGBDBM35733(sulfonamide deriv., 7a)
Affinity DataKi:  84nMAssay Description:Inhibition of human carbonic anhydrase-9 by stopped flow CO2 hydrase assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed

TargetCarbonic anhydrase 9(Human)
University of Florida

Curated by ChEMBL
LigandPNGBDBM35733(sulfonamide deriv., 7a)
Affinity DataKi:  84nMAssay Description:Inhibition of human CA9 by stopped-flow CO2 hydrase assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed

TargetCarbonic anhydrase 2(Human)
The Hebrew University of Jerusalem

Curated by ChEMBL
LigandPNGBDBM35733(sulfonamide deriv., 7a)
Affinity DataKi:  107nMAssay Description:Inhibition of human recombinant carbonic anhydrase 2 by stopped flow CO2 hydration methodMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMedPDB3D3D Structure (crystal)

TargetCarbonic anhydrase 2(Human)
The Hebrew University of Jerusalem

Curated by ChEMBL
LigandPNGBDBM35733(sulfonamide deriv., 7a)
Affinity DataKi:  107nM ΔG°:  -9.50kcal/molepH: 7.4 T: 25°CAssay Description:An SX.18MV-R Applied Photophysics (Oxford, UK) stopped-flow instrument has been used to assay the catalytic/inhibition of various CA isozymes. Phenol...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMedPDB3D3D Structure (crystal)

TargetCarbonic anhydrase 1(Human)
The Hebrew University of Jerusalem

Curated by ChEMBL
LigandPNGBDBM35733(sulfonamide deriv., 7a)
Affinity DataKi:  108nM ΔG°:  -9.50kcal/molepH: 7.4 T: 25°CAssay Description:An SX.18MV-R Applied Photophysics (Oxford, UK) stopped-flow instrument has been used to assay the catalytic/inhibition of various CA isozymes. Phenol...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed

TargetCarbonic anhydrase 1(Human)
The Hebrew University of Jerusalem

Curated by ChEMBL
LigandPNGBDBM35733(sulfonamide deriv., 7a)
Affinity DataKi:  108nMAssay Description:Inhibition of human recombinant carbonic anhydrase 1 by stopped flow CO2 hydration methodMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed