BDBM362032 (S)-3-(2-(1-((2-amino-5-cyano-6-(difluoromethyl)pyrimidin-4-yl)amino)ethyl)-5-chloro-4-oxoquinazolin-3(4H)-yl)benzamide::US10221197, Compound 25::US10221197, Compound 26

SMILES C[C@H](Nc1nc(N)nc(C(F)F)c1C#N)c1nc2c(Cl)cc(F)cc2c(=O)n1-c1cccc(c1)C(N)=O

InChI Key InChIKey=HVIXLGUBYXXBAI-VIFPVBQESA-N

Data  6 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
Find this compound or compounds like it in BindingDB:
   Substructure
Similarity at least:  must be >=0.5
Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 6 hits for monomerid = 362032   

TargetPhosphatidylinositol 3-kinase regulatory subunit beta(Human)
Gilead Sciences

US Patent
LigandPNGBDBM362032((S)-3-(2-(1-((2-amino-5-cyano-6-(difluoromethyl)py...)
Affinity DataIC50:  2.40E+4nMAssay Description:TR-FRET monitored the formation of 3,4,5-inositol triphosphate molecule that competed with fluorescently labeled PIP3 for binding to the GRP-1 plecks...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent

LigandPNGBDBM362032((S)-3-(2-(1-((2-amino-5-cyano-6-(difluoromethyl)py...)
Affinity DataIC50:  1.00E+3nMMore data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent

LigandPNGBDBM362032((S)-3-(2-(1-((2-amino-5-cyano-6-(difluoromethyl)py...)
Affinity DataIC50:  7.20E+6nMMore data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent

TargetPhosphatidylinositol 3-kinase regulatory subunit beta(Human)
Gilead Sciences

US Patent
LigandPNGBDBM362032((S)-3-(2-(1-((2-amino-5-cyano-6-(difluoromethyl)py...)
Affinity DataIC50:  3.13E+5nMAssay Description:TR-FRET monitored the formation of 3,4,5-inositol triphosphate molecule that competed with fluorescently labeled PIP3 for binding to the GRP-1 plecks...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent

LigandPNGBDBM362032((S)-3-(2-(1-((2-amino-5-cyano-6-(difluoromethyl)py...)
Affinity DataIC50:  1.20E+4nMMore data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent

LigandPNGBDBM362032((S)-3-(2-(1-((2-amino-5-cyano-6-(difluoromethyl)py...)
Affinity DataIC50:  7.00E+5nMMore data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent