BDBM362347 N-(3-(7-(1H-indol-2-yl)-5H-pyrrolo[2,3-b]pyrazin-2-yl)phenyl)acrylamide ::US9834551, Example 3

SMILES Clc1ccc2cc([nH]c2c1)-c1c[nH]c2ncc(nc12)-c1cccc(NC(=O)C=C)c1

InChI Key InChIKey=ZMVOCEZRJJVAOX-UHFFFAOYSA-N

Data  2 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
Find this compound or compounds like it in BindingDB:
   Substructure
Similarity at least:  must be >=0.5
Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 2 hits for monomerid = 362347   

TargetTyrosine-protein kinase JAK3(Homo sapiens (Human))
Arrien Pharmaceuticals

US Patent
LigandPNGBDBM362347(N-(3-(7-(1H-indol-2-yl)-5H-pyrrolo[2,3-b]pyrazin-2...)
Affinity DataIC50: >100nMAssay Description:ITK and JAK3 Kinase assay procedures:Enzyme was incubated with substrate peptide in reaction buffer in the presence and absence of test compounds or ...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent
TargetTyrosine-protein kinase ITK/TSK(Homo sapiens (Human))
Arrien Pharmaceuticals

US Patent
LigandPNGBDBM362347(N-(3-(7-(1H-indol-2-yl)-5H-pyrrolo[2,3-b]pyrazin-2...)
Affinity DataIC50: >100nMAssay Description:ITK and JAK3 Kinase assay procedures:Enzyme was incubated with substrate peptide in reaction buffer in the presence and absence of test compounds or ...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent