BDBM365055 4-(3-isobutyl-5-methyl-4,5- dihydro-3H-1,2,2a1,5- tetraazaacenaphthylen-7-yl)- N-(1-methyl-1H-pyrazol-5- yl)pyridin-2-amine::US10278975, Compound I-20 R::US11376260, Example I-20R::US9867833, Compound I-20(R)::US9867833, Compound I-20(S)

SMILES CC(C)C[C@@H]1CN(C)c2cc(cc3nnc1n23)-c1ccnc(Nc2ccnn2C)c1

InChI Key InChIKey=RBGSJRZOFZEZPV-UHFFFAOYSA-N

Data  4 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 4 hits for monomerid = 365055   

TargetMitogen-activated protein kinase 1(Human)
Genentech

US Patent
LigandChemical structure of BindingDB Monomer ID 365055BDBM365055(US9867833, Compound I-20(R) | 4-(3-isobutyl-5-meth...)
Affinity DataIC50: 0.316nMAssay Description:Compounds were tested in an enzymatic assay using human ERK-2 (Mitogen Activated Kinase 1), recombinantly expressed as an n-terminal 6-His fusion pro...More data for this Ligand-Target Pair
In Depth
Date in BDB:
12/10/2019
Entry Details
US Patent

TargetMitogen-activated protein kinase 1(Human)
Genentech

US Patent
LigandChemical structure of BindingDB Monomer ID 365055BDBM365055(US9867833, Compound I-20(R) | 4-(3-isobutyl-5-meth...)
Affinity DataIC50: 48.7nMAssay Description:Compounds were tested in an enzymatic assay using human ERK-2 (Mitogen Activated Kinase 1), recombinantly expressed as an n-terminal 6-His fusion pro...More data for this Ligand-Target Pair
In Depth
Date in BDB:
2/21/2020
Entry Details
US Patent

TargetMitogen-activated protein kinase 6(Human)
Genentech

US Patent
LigandChemical structure of BindingDB Monomer ID 365055BDBM365055(US9867833, Compound I-20(R) | 4-(3-isobutyl-5-meth...)
Affinity DataIC50: 48.7nMAssay Description:Compounds were tested in an enzymatic assay using human ERK-2 (Mitogen Activated Kinase 1), recombinantly expressed as an n-terminal 6-His fusion pro...More data for this Ligand-Target Pair
In Depth
Date in BDB:
10/5/2022
Entry Details
US Patent

TargetMitogen-activated protein kinase 1(Human)
Genentech

US Patent
LigandChemical structure of BindingDB Monomer ID 365055BDBM365055(US9867833, Compound I-20(R) | 4-(3-isobutyl-5-meth...)
Affinity DataIC50: 48.7nMAssay Description:Compounds were tested in an enzymatic assay using human ERK-2 (Mitogen Activated Kinase 1), recombinantly expressed as an n-terminal 6-His fusion pro...More data for this Ligand-Target Pair
In Depth
Date in BDB:
12/10/2019
Entry Details
US Patent