BDBM374668 3-((S)-1-((3R,4S)-1-(1-((R)-1-(4-Chloro-2-fluorophenyl)ethyl)-3-methyl-1H-pyrazolo[3,4-b]pyrazin-6-yl)-3-methylpiperidin-4-yl)pyrrolidin-2-yl)propanoic acid 2,2,2-trifluoroacetate::US10246462, Example 49

SMILES C[C@H](c1ccc(Cl)cc1F)n1nc(C)c2ncc(nc12)N1CCC([C@H](C)C1)N1CCC[C@H]1CCC(O)=O

InChI Key InChIKey=SIEJRLDGKHLLJJ-BKWPFJTKSA-N

Data  1 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 1 hit for monomerid = 374668   

TargetC-C chemokine receptor type 4(Homo sapiens (Human))
Flx Bio

US Patent
LigandPNGBDBM374668(3-((S)-1-((3R,4S)-1-(1-((R)-1-(4-Chloro-2-fluoroph...)
Affinity DataIC50:  300nMAssay Description:To measure binding of 125I-TARC or 125I-MDC to cells expressing CCR4 (e.g., CEM cells (e.g., ATCC HB-12624)), the 125I-TARC or 125I-MDC is diluted to...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent