BDBM377822 (R)-5-amino-1-(1-cyanopiperidin-3-yl)-3-(4-((6-(trifluoromethyl)pyridin-2-yl)oxy)phenyl)-1H-pyrazole-4-carboxamide::US10266513, Example 116::US10266513, Example 117

SMILES NC(=O)c1c(N)n(nc1-c1ccc(Oc2cccc(n2)C(F)(F)F)cc1)C1CCCN(C1)C#N

InChI Key InChIKey=LNMYMSAHQVYVMW-UHFFFAOYSA-N

Data  3 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 3 hits for monomerid = 377822   

TargetTyrosine-protein kinase BTK(Human)
Pfizer

US Patent
LigandChemical structure of BindingDB Monomer ID 377822BDBM377822((R)-5-amino-1-(1-cyanopiperidin-3-yl)-3-(4-((6-(tr...)
Affinity DataIC50: 2.60nMAssay Description:TR-FRET LanthaScreen assays were performed by incubating a dilution series of inhibitor concentrations with 50 μM ATP, 100 nM FAM-Srctide peptid...More data for this Ligand-Target Pair
In Depth
Date in BDB:
2/7/2020
Entry Details
US Patent

TargetTyrosine-protein kinase BTK(Human)
Pfizer

US Patent
LigandChemical structure of BindingDB Monomer ID 377822BDBM377822((R)-5-amino-1-(1-cyanopiperidin-3-yl)-3-(4-((6-(tr...)
Affinity DataIC50: 18.9nMAssay Description:TR-FRET LanthaScreen assays were performed by incubating a dilution series of inhibitor concentrations with 50 μM ATP, 100 nM FAM-Srctide peptid...More data for this Ligand-Target Pair
In Depth
Date in BDB:
2/7/2020
Entry Details
US Patent

TargetEpidermal growth factor receptor(Human)
Pfizer

US Patent
LigandChemical structure of BindingDB Monomer ID 377822BDBM377822((R)-5-amino-1-(1-cyanopiperidin-3-yl)-3-(4-((6-(tr...)
Affinity DataIC50: 2.68E+4nMAssay Description:TR-FRET LanthaScreen assays were performed by incubating a dilution series of inhibitor concentrations with 20 μM ATP, 100 nM peptide substrate ...More data for this Ligand-Target Pair
In Depth
Date in BDB:
2/7/2020
Entry Details
US Patent