BDBM380178 5-fluoro-N-[4-(4-oxo- 3,4-dihydrophthalazin-1- yl)phenyl]-1-(oxolan-3- ylmethyl)-1H-indazole- 3-carboxamide::US9926282, Example 173

SMILES Fc1ccc2n(CC3CCOC3)nc(C(=O)Nc3ccc(cc3)-c3n[nH]c(=O)c4ccccc34)c2c1

InChI Key InChIKey=NFUPGCMFZSRLJK-UHFFFAOYSA-N

Data  2 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 2 hits for monomerid = 380178   

TargetRho-associated protein kinase 2(Human)
Bristol-Myers Squibb

US Patent
LigandChemical structure of BindingDB Monomer ID 380178BDBM380178(5-fluoro-N-[4-(4-oxo- 3,4-dihydrophthalazin-1- yl)...)
Affinity DataIC50: 100nMAssay Description:The effectiveness of compounds of the present invention as ROCK inhibitors can be determined in a 30 μL assay containing 20 mM HEPES, pH 7.5, 20...More data for this Ligand-Target Pair
In Depth
Date in BDB:
2/10/2020
Entry Details
US Patent

TargetRho-associated protein kinase 1(Human)
Bristol-Myers Squibb

US Patent
LigandChemical structure of BindingDB Monomer ID 380178BDBM380178(5-fluoro-N-[4-(4-oxo- 3,4-dihydrophthalazin-1- yl)...)
Affinity DataIC50: 100nMAssay Description:The effectiveness of compounds of the present invention as ROCK inhibitors can be determined in a 30 μL assay containing 20 mM HEPES, pH 7.5, 20...More data for this Ligand-Target Pair
In Depth
Date in BDB:
2/10/2020
Entry Details
US Patent