BDBM387172 3-(5-((5-chloro-2-((1-(6-methoxypyridin-3-yl)-1H-pyrazol-4-yl)amino)pyrimidin-4-yl)amino)hexahydrocyclopenta[c]pyrrol-2(1H)-yl)-3-oxopropanenitrile::US9938257, Example 10

SMILES COc1ccc(cn1)-n1cc(Nc2ncc(Cl)c(NC3CC4CN(CC4C3)C(=O)CC#N)n2)cn1

InChI Key InChIKey=YBOBJBRACZBMOB-UHFFFAOYSA-N

Data  3 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
Find this compound or compounds like it in BindingDB:
   Substructure
Similarity at least:  must be >=0.5
Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 3 hits for monomerid = 387172   

TargetTyrosine-protein kinase JAK1(Homo sapiens (Human))
Calitor Sciences

US Patent
LigandPNGBDBM387172(3-(5-((5-chloro-2-((1-(6-methoxypyridin-3-yl)-1H-p...)
Affinity DataIC50: <0.300nMAssay Description:JAK1:Kinase assays can be performed by measurement of incorporation of γ-33P ATP into immobilized myelin basic protein (MBP). High binding white...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent
TargetTyrosine-protein kinase JAK2(Homo sapiens (Human))
Calitor Sciences

US Patent
LigandPNGBDBM387172(3-(5-((5-chloro-2-((1-(6-methoxypyridin-3-yl)-1H-p...)
Affinity DataIC50:  16nMAssay Description:JAK2:Kinase assays can be performed by measurement of incorporation of γ-33P ATP into immobilized myelin basic protein (MBP). High binding white...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent
TargetAurora kinase A(Homo sapiens (Human))
Calitor Sciences

US Patent
LigandPNGBDBM387172(3-(5-((5-chloro-2-((1-(6-methoxypyridin-3-yl)-1H-p...)
Affinity DataIC50:  4nMAssay Description:Aurora-A:Kinase assays can be performed by measurement of incorporation of γ-33P ATP into immobilized myelin basic protein (MBP). High binding w...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent