BDBM389377 US9951027, 2-151-2
SMILES COC(=O)c1cc2nc(Nc3ccc(cc3)C(C)C)n([C@H]3C[C@H](C)CC(C)(C)C3)c2cc1OC
InChI Key InChIKey=RTYBYVPYYMCJDN-RXVVDRJESA-N
Data 1 IC50
Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB
Found 1 hit for monomerid = 389377
TargetIsocitrate dehydrogenase [NADP] cytoplasmic [R132H](Homo sapiens (Human))
Bayer Pharma Aktiengesellschaft
US Patent
Bayer Pharma Aktiengesellschaft
US Patent
Affinity DataIC50: 20nMAssay Description:mIDH1 catalyzes the NADPH-dependent reduction of alpha-ketoglutarate (α-KG) to (2R)-2-hydroxyglutarate (2-HG). NADPH consumption was measured by...More data for this Ligand-Target Pair