BDBM393947 US9969749, Example 1-40::trans-N'-{6-[5-(2- methoxyethoxy)pyridin- 3-yl]quinazolin-4-yl}- N,N- dimethylcyclohexane- 1,4-diamine

SMILES COCCOc1cncc(-c2ccc3ncnc(N[C@H]4CC[C@H](N(C)C)CC4)c3c2)c1

InChI Key InChIKey=LCWPQWBNOUNINY-UHFFFAOYSA-N

Data  1 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
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Similarity at least:  must be >=0.5
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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 1 hit for monomerid = 393947   

TargetInterleukin-1 receptor-associated kinase 4(Human)
Merck Sharp & Dohme

US Patent
LigandChemical structure of BindingDB Monomer ID 393947BDBM393947(US9969749, Example 1-40 | trans-N'-{6-[5-(2- metho...)
Affinity DataIC50: 83nMAssay Description:The kinase activity of IRAK4 is determined by its ability to catalyze the phosphorylation of a fluorescent polypeptide substrate. The extent of phosp...More data for this Ligand-Target Pair
In Depth
Date in BDB:
4/6/2020
Entry Details
US Patent