BDBM402820 2-{[(1S,2R)- or (1R,2S)-2- amino-4,4- difluorocyclohexyl]amino}- N-[1-methyl-3- (trifluoromethyl)-1H- pyrazol-4-yl]pyrrolo[2,1- f][1,2,4]triazine-7- carboxamide trifluoroacetate::US10329295, Example 132

SMILES Cn1cc(NC(=O)c2ccc3cnc(N[C@@H]4CCC(F)(F)C[C@@H]4N)nn23)c(n1)C(F)(F)F

InChI Key InChIKey=UBWZJANMJSSVFU-UHFFFAOYSA-N

Data  1 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 1 hit for monomerid = 402820   

TargetInterleukin-1 receptor-associated kinase 4(Human)
Merck Sharp & Dohme

US Patent
LigandChemical structure of BindingDB Monomer ID 402820BDBM402820(US10329295, Example 132 | 2-{[(1S,2R)- or (1R,2S)-...)
Affinity DataIC50: 655nMAssay Description:The kinase activity of IRAK4 is determined by its ability to catalyze the phosphorylation of a fluorescent polypeptide substrate. The extent of phosp...More data for this Ligand-Target Pair
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Date in BDB:
5/31/2020
Entry Details
US Patent