BDBM406054 1-(1',4-dimethyl-1-phenyl- 1H,1'H-3,4'-bipyrazol-5-yl)-3- (isochroman-4-yl)urea::US10351575, Example 8::US10889589, EX. # 8

SMILES Cc1c(NC(=O)NC2COCc3ccccc23)n(nc1-c1cnn(C)c1)-c1ccccc1

InChI Key InChIKey=VVWSQBOTKJUUBJ-UHFFFAOYSA-N

Data  2 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
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Similarity at least:  must be >=0.5
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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 2 hits for monomerid = 406054   

TargetHigh affinity nerve growth factor receptor(Human)
Array Biopharma

US Patent
LigandChemical structure of BindingDB Monomer ID 406054BDBM406054(1-(1',4-dimethyl-1-phenyl- 1H,1'H-3,4'-bipyrazol-5...)
Affinity DataIC50: 550nMAssay Description:TrkA binding activity was determined in a TrkA LanthaScreen Eu Kinase Binding Assay. 5 nM His-tagged recombinant human TrkA (6HIS tagged cytoplasmic ...More data for this Ligand-Target Pair
In Depth
Date in BDB:
8/9/2021
Entry Details
US Patent

TargetHigh affinity nerve growth factor receptor(Human)
Array Biopharma

US Patent
LigandChemical structure of BindingDB Monomer ID 406054BDBM406054(1-(1',4-dimethyl-1-phenyl- 1H,1'H-3,4'-bipyrazol-5...)
Affinity DataIC50: 550nMAssay Description:TrkA binding activity was determined in a TrkA LanthaScreen Eu Kinase Binding Assay. 5 nM His-tagged recombinant human TrkA (6HIS tagged cytoplasmic ...More data for this Ligand-Target Pair
In Depth
Date in BDB:
6/12/2020
Entry Details
US Patent