BDBM406163 1-(6-(methoxymethyl)-1- methyl-2-(2,2,2- trifluoroethyl)-1,2,3,4- tetrahydroisoquinolin-4- yl)-3-(4-methyl-3-(1- methyl-1H-imidazol-4- yl)-1-phenyl-1H-pyrazol- 5-yl)urea::US10351575, Example 111::US10889589, EX. # 111

SMILES COCc1ccc2C(C)N(CC(F)(F)F)CC(NC(=O)Nc3c(C)c(nn3-c3ccccc3)-c3cn(C)cn3)c2c1

InChI Key InChIKey=QRJNYZPGUMDQSI-UHFFFAOYSA-N

Data  2 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
Find this compound or compounds like it in BindingDB:
   Substructure
Similarity at least:  must be >=0.5
Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 2 hits for monomerid = 406163   

TargetHigh affinity nerve growth factor receptor(Human)
Array Biopharma

US Patent
LigandChemical structure of BindingDB Monomer ID 406163BDBM406163(1-(6-(methoxymethyl)-1- methyl-2-(2,2,2- trifluoro...)
Affinity DataIC50: 100nMAssay Description:TrkA binding activity was determined in a TrkA LanthaScreen Eu Kinase Binding Assay. 5 nM His-tagged recombinant human TrkA (6HIS tagged cytoplasmic ...More data for this Ligand-Target Pair
In Depth
Date in BDB:
6/12/2020
Entry Details
US Patent

TargetHigh affinity nerve growth factor receptor(Human)
Array Biopharma

US Patent
LigandChemical structure of BindingDB Monomer ID 406163BDBM406163(1-(6-(methoxymethyl)-1- methyl-2-(2,2,2- trifluoro...)
Affinity DataIC50: 100nMAssay Description:TrkA binding activity was determined in a TrkA LanthaScreen Eu Kinase Binding Assay. 5 nM His-tagged recombinant human TrkA (6HIS tagged cytoplasmic ...More data for this Ligand-Target Pair
In Depth
Date in BDB:
8/9/2021
Entry Details
US Patent