BDBM408483 4-ethynyl-6-((4-methoxybenzyl)oxy)- 2-methylpyrimidine::US10358435, Example 5

SMILES COc1ccc(COc2cc(nc(C)n2)C#C)cc1

InChI Key InChIKey=FDNJXCPJASNUMI-UHFFFAOYSA-N

Data  1 KI

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 1 hit for monomerid = 408483   

TargetcGMP-dependent 3',5'-cyclic phosphodiesterase(Human)
Merck Sharp & Dohme

US Patent
LigandChemical structure of BindingDB Monomer ID 408483BDBM408483(4-ethynyl-6-((4-methoxybenzyl)oxy)- 2-methylpyrimi...)
Affinity DataKi:  52.2nMAssay Description:In a typical experiment the PDE2 inhibitory activity of the compounds of the present invention was determined in accordance with the following experi...More data for this Ligand-Target Pair
In Depth
Date in BDB:
6/21/2020
Entry Details
US Patent