BDBM409560 2-[6-(5-Chloro-4-methyl-2-thienyl)pyrrolo[3,2-b]pyridin-1-yl]-::US10377753, Example 426
SMILES CN(C)C(=O)Cn1ccc2ncc(cc12)-c1cc(C)c(Cl)s1
InChI Key InChIKey=TXOONESNPOIHIY-UHFFFAOYSA-N
Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB
Found 5 hits for monomerid = 409560
Affinity DataKi: 4.30nMAssay Description:Displacement of [3H]-1-(azetidin-1-yl)-2-(6-(4-fluoro-3-methylphenyl)-1H-pyrrolo[3,2-b]pyridin-1-yl)ethanone from rat adult cortex GluN2B receptor me...More data for this Ligand-Target Pair
TargetGlutamate receptor ionotropic, NMDA 1/2B(Human)
Janssen Research & Development
Curated by ChEMBL
Janssen Research & Development
Curated by ChEMBL
Affinity DataIC50: 21nMAssay Description:Negative allosteric modulation of recombinant human GluN1a/GluN2B expressed in CHO-T-REx cells assessed as inhibition of glutamate/glycine-induced re...More data for this Ligand-Target Pair
TargetPotassium voltage-gated channel subfamily H member 2(Human)
Janssen Research & Development
Curated by ChEMBL
Janssen Research & Development
Curated by ChEMBL
Affinity DataIC50: >1.00E+4nMAssay Description:Displacement of [3H]dofetilide from recombinant human ERG expressed in HEK293 cell membranes measured after 80 mins by TopCount scintillation analysi...More data for this Ligand-Target Pair
Affinity DataIC50: 8.40E+3nMAssay Description:Inhibition of CYP2C19 in human liver microsomesMore data for this Ligand-Target Pair
Affinity DataIC50: 79.4nMAssay Description:The assay depends on the binding of a tracer to the GluN2B subunit-containing NMDA receptors and the ability of the test compounds to displace such b...More data for this Ligand-Target Pair