BDBM417399 2-(6-{5-chloro-2- [(oxan-4-yl)amino] pyrimidin-4-yl)-1-oxo- 2,3-dihydro-1H- isoindol-2-yl)-N-(1,1,1- trifluoro-2- methylpropan-2- yl)acetamide::US10457669, Example 11::US11001575, Example 11

SMILES CC(C)(NC(=O)CN1Cc2ccc(cc2C1=O)-c1nc(NC2CCOCC2)ncc1Cl)C(F)(F)F

InChI Key InChIKey=BNOJINNRBHGKNN-UHFFFAOYSA-N

Data  2 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 2 hits for monomerid = 417399   

TargetMitogen-activated protein kinase 1(Human)
Otsuka Pharmaceutical

US Patent
LigandPNGBDBM417399(2-(6-{5-chloro-2- [(oxan-4-yl)amino] pyrimidin-4-y...)
Affinity DataIC50:  1.90nMAssay Description:Activity of ERK2 enzyme (Life Technologies) was determined using a time-resolved fluorescence format measuring the phosphorylation of a truncated ver...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent


TargetMitogen-activated protein kinase 1(Human)
Otsuka Pharmaceutical

US Patent
LigandPNGBDBM417399(2-(6-{5-chloro-2- [(oxan-4-yl)amino] pyrimidin-4-y...)
Affinity DataIC50:  1.90nMAssay Description:Activity of ERK2 enzyme (Life Technologies) was determined using a time-resolved fluorescence format measuring the phosphorylation of a truncated ver...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent